Evidence map›Paper›PMID 30082908›Full record

ArticleNature communications2018

Optical imaging of metabolic dynamics in animals.

Lingyan Shi, Chaogu Zheng, Yihui Shen, Zhixing Chen, Edilson S Silveira, Luyuan Zhang, Mian Wei, Chang Liu, Carmen de Sena-Tomas, Kimara Targoff and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 251 citations in OpenAlex.

  1. Review
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  15. Bond-Selective Imaging at the Frontier of Biomedicine.Chemical & biomedical imaging · 2025
    Article
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  18. Article
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lingyan ShiDepartment of Chemistry, Columbia University, New York, NY, 10027, USA.ORCID http://orcid.org/0000-0003-1373-3206
Chaogu ZhengDepartment of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Yihui ShenDepartment of Chemistry, Columbia University, New York, NY, 10027, USA.
Zhixing ChenDepartment of Chemistry, Columbia University, New York, NY, 10027, USA.
Edilson S SilveiraDepartment of Chemistry, Columbia University, New York, NY, 10027, USA.
Luyuan ZhangDepartment of Chemistry, Columbia University, New York, NY, 10027, USA.
Mian WeiDepartment of Chemistry, Columbia University, New York, NY, 10027, USA.
Chang LiuDepartment of Chemistry, Columbia University, New York, NY, 10027, USA.
Carmen de Sena-TomasDepartment of Pediatrics, Columbia University, New York, NY, 10027, USA.
Kimara TargoffDepartment of Pediatrics, Columbia University, New York, NY, 10027, USA.
Wei MinDepartment of Chemistry, Columbia University, New York, NY, 10027, USA. wm2256@columbia.edu.ORCID http://orcid.org/0000-0003-2570-3557
Columbia University · US

Funding

GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR01GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1985 to 2017
$7.1M
GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR37GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1999 to 2009
$6.6M
Genetic analysis of nematode cell differentiationR35GM122522 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MARTIN CHALFIE · 2017 to 2026
$6.5M
Label-Free Chemical Imaging for Biological ApplicationsDP2EB016573 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MIN, WEI · 2012 to 2012
$2.4M
Mechanisms of second heart field development regulated by Nkx genesR01HL131438 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TARGOFF, KIMARA L · 2017 to 2021
$2.1M
Optical imaging of small bio-molecules in living cells and tissues by nonlinear Raman microscopy coupled with vibrational tagsR01EB020892 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MIN, WEI · 2015 to 2018
$1.3M
NHLBI NIH HHS R01 HL131438NIBIB NIH HHS DP2 EB016573NIBIB NIH HHS R01 EB020892NIGMS NIH HHS R01 GM030997NIGMS NIH HHS R35 GM122522NIGMS NIH HHS R37 GM030997
6 · The paper itself

Abstract

Direct visualization of metabolic dynamics in living animals with high spatial and temporal resolution is essential to understanding many biological processes. Here we introduce a platform that combines deuterium oxide (D

Indexed as

MetabolismSpectrum Analysis, RamanAnimalsCaenorhabditis elegansCarbonCell Line, TumorChlorocebus aethiopsContrast MediaCOS CellsDeuteriumDeuterium OxideHeLa CellsHumansImage Processing, Computer-AssistedLipid MetabolismLipidsCarbonContrast MediaDeuteriumDeuterium OxideLipidsMacromolecular Substances

Identifiers

PMID30082908
PMCPMC6079036
OpenAlexW2952902070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.