ArticleScientific reports2018
Characterization of Der f 22 - a paralogue of the major allergen Der f 2.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comment on "Characterization of a major house dust mite allergen Der p 22 among Malaysian adult population".The World Allergy Organization journal · 2025Article
- Characterization of a major house dust mite allergen Der p 22 among Malaysian adult population.The World Allergy Organization journal · 2025Article
- A systematic review of allergen cross-reactivity: Translating basic concepts into clinical relevance.The journal of allergy and clinical immunology. Global · 2024Review
- Blo t 2: Group 2 allergen from the dust mite Blomia tropicalis.Scientific reports · 2019Article
- The major allergen Der p 2 is a cholesterol binding protein.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We previously identified an expressed sequence tag clone, Der f 22, showing 41% amino acid identity to published Der f 2, and show that both genes are possible paralogues. The objective of this study was to characterize the genomic, proteomic and immunological functions Der f 22 and Der f 2. The full-length sequence of Der f 2 and Der f 22 coded for mature proteins of 129 and 135 amino acids respectively, both containing 6 cysteine residues. Phylogenetic analysis of known group 2 allergens and their homologues from our expressed sequence tag library showed that Der f 22 is a paralogue of Der f 2. Both Der f 2 and Der f 22 were single gene products with one intron. Both allergens showed specific IgE-binding to over 40% of the atopic patients, with limited of cross-reactivity. Both allergens were detected at the gut region of D. farinae by immunostaining. Der f 22 is an important allergen with significant IgE reactivity among the atopic population, and should be considered in the diagnostic panel and evaluated as future hypoallergen vaccine therapeutic target.
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