ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Disentangling the genetic overlap between cholesterol and suicide risk.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion inCirculation. Genomic and precision medicine · 2021Trial
- Low 5HTJournal of neurochemistry · 2026Review
- Article
- Immune-metabolic dysregulation and suicide risk in adolescents with major depressive disorder: a cross-sectional study.BMC psychiatry · 2026Article
- Metabolic syndrome increases the risk of suicide attempt: evidence from a population-based cohort and genomic analysis.Translational psychiatry · 2025Article
- Transcriptomic and Proteomic Analyses of the Liver and Ileum Identify Key Genes and Pathways Associated with Low and High Groups of Social Genetic Effect of Residual Feed Intake.Animals : an open access journal from MDPI · 2025Article
- Biological Basis for the Formation of Suicidal Behavior: A Review.Medical journal of the Islamic Republic of Iran · 2025Review
- The Relationship Between CYP46A1 Polymorphism and Suicide Risk: A Preliminary Investigation.Neuromolecular medicine · 2024Article
- Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Article
- Suicide Biomarkers to Predict Risk, Classify Diagnostic Subtypes, and Identify Novel Therapeutic Targets: 5 Years of Promising Research.The international journal of neuropsychopharmacology · 2022Review
- Bioimpedance Body Measures and Serum Lipid Levels in Masculine Depression.Frontiers in psychiatry · 2022Article
- Suicide capability within the ideation-to-action framework: A systematic scoping review.PloS one · 2022Article
- Development of a Suicide Prediction Model for the Elderly Using Health Screening Data.International journal of environmental research and public health · 2021Article
- Review
- Are Lipids Possible Markers of Suicide Behaviors?Journal of clinical medicine · 2021Review
- Lipids and Suicide Risk.Current topics in behavioral neurosciences · 2020Article
- Cholesterol Biosynthesis and Uptake in Developing Neurons.ACS chemical neuroscience · 2019Article
- Shared Genetics of Psychiatric Disorders.F1000Research · 2019Review
- The Association Between Dyslipidemia and Lethality of Suicide Attempts: A Case-Control Study.Frontiers in psychiatry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 2 countries.
Funding
Abstract
Suicide is major public health concern; one million individuals worldwide die by suicide each year of which there are many more attempts. Thus, it is imperative that robust and reliable indicators, or biomarkers, of suicide risk be identified so that individuals at risk can be identified and provided appropriate interventions as quickly as possible. Previous work has revealed a relationship between low levels of circulating cholesterol and suicide risk, implicating cholesterol level as one such potential biomarker, but the factors underlying this relationship remain unknown. In the present study, we applied a combination of bivariate polygenic and coefficient-of-relatedness analysis, followed by mediation analysis, in a large sample of Mexican-American individuals from extended pedigrees [N = 1897; 96 pedigrees (average size = 19.17 individuals, range = 2-189) 60% female; mean age = 42.58 years, range = 18-97 years, sd = 15.75 years] with no exclusion criteria for any given psychiatric disorder. We observed that total esterified cholesterol measured at the time of psychiatric assessment shared a significant genetic overlap with risk for suicide attempt (ρ
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.