ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory.Behavioral neuroscience · 2022Pooled it
- An ace in the hole? Opportunities and limits of using mice to understand schizophrenia neurobiology.Molecular psychiatry · 2025Review
- Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Dampened motivation in schizophrenia: evidence from a novel effort-based decision-making task in social scenarios.European archives of psychiatry and clinical neuroscience · 2024Article
- Article
- Refining the study of decision-making in animals: differential effects of d-amphetamine and haloperidol in a novel touchscreen-automated Rearing-Effort Discounting (RED) task and the Fixed-Ratio Effort Discounting (FRED) task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Short-active gestational photoperiod reduces effortful choice behavior in mice, partial normalization by d-amphetamine.Psychopharmacology · 2023Article
- Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort.eLife · 2022Article
- Vigor, Effort-Related Aspects of Motivation and Anhedonia.Current topics in behavioral neurosciences · 2022Review
- How changes in dopamine D2 receptor levels alter striatal circuit function and motivation.Molecular psychiatry · 2022Review
- Chronic social defeat stress impairs goal-directed behavior through dysregulation of ventral hippocampal activity in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Dopamine D2R upregulation in ventral striatopallidal neurons does not affect Pavlovian or go/no-go learning.Behavioral neuroscience · 2021Article
- Orbitofrontal-Striatal Structural Alterations Linked to Negative Symptoms at Different Stages of the Schizophrenia Spectrum.Schizophrenia bulletin · 2021Article
- Disruptions in effort-based decision-making following acute optogenetic stimulation of ventral tegmental area dopamine cells.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Dopamine D2 receptor signaling on iMSNs is required for initiation and vigor of learned actions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- The dopamine depleting agent tetrabenazine alters effort-related decision making as assessed by mouse touchscreen procedures.Psychopharmacology · 2020Article
- Emerging roles of striatal dopamine D2 receptors in motivated behaviour: Implications for psychiatric disorders.Basic & clinical pharmacology & toxicology · 2020Review
- A low dosage of the dopamine D2-receptor antagonist sulpiride affects effort allocation for reward regardless of trait extraversion.Personality neuroscience · 2020Article
- Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restriction.Psychopharmacology · 2020Article
- Overexpression of striatal D2 receptors reduces motivation thereby decreasing food anticipatory activity.The European journal of neuroscience · 2020Article
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7 authors.
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Abstract
Deficits in goal-directed motivation represent a debilitating symptom for many patients with schizophrenia. Impairments in motivation can arise from deficits in processing information about effort and or value, disrupting effective cost-benefit decision making. We have previously shown that upregulated dopamine D2 receptor expression within the striatum (D2R-OE mice) decreases goal-directed motivation. Here, we determine the behavioral and neurochemical mechanisms behind this deficit. Female D2R-OE mice were tested in several behavioral paradigms including recently developed tasks that independently assess the impact of Value or Effort manipulations on cost-benefit decision making. In vivo microdialysis was used to measure extracellular dopamine in the striatum during behavior. In a value-based choice task, D2R-OE mice show normal sensitivity to changes in reward value and used reward value to guide their actions. In an effort-based choice task, D2R-OE mice evaluate the cost of increasing the number of responses greater relative to the effort cost of longer duration responses compared to controls. This shift away from choosing to repeatedly execute a response is accompanied by a dampening of extracellular dopamine in the striatum during goal-directed behavior. In the ventral striatum, extracellular dopamine level negatively correlates with response cost in controls, but this relationship is lost in D2R-OE mice. These results show that D2R signaling in the striatum, as observed in some patients with schizophrenia, alters the relationship between effort expenditure and extracellular dopamine. This dysregulation produces motivation deficits that are specific to effort but not value-based decision making, paralleling the effort-based motivational deficits observed in schizophrenia.
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