Evidence map›Paper›PMID 30082840›Full record

ArticleMolecular psychiatry2019

Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [

Siamak Nejad-Davarani, Robert A Koeppe, Roger L Albin, Kirk A Frey, Martijn L T M Müller, Nicolaas I Bohnen

Registry-linked trialOpen access · greenAbstract readLetterComment
In one paragraph

Article in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04291144 (Visualising the Cerebral Cholinergic Innervation and Parasympathetic Gastrointestinal Nerves in Patients With Dementia Lewy Bodies.), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04291144 completednot on this mapstarted 2020, after this paper: background citation

Visualising the Cerebral Cholinergic Innervation and Parasympathetic Gastrointestinal Nerves in Patients With Dementia Lewy Bodies.

TypeobservationalSponsorUniversity of AarhusRan2020 to 2023Enrolled40ConditionsDementia With Lewy Bodies, Degeneration Nerves, Positron-Emission Tomography, AcetylcholineArmsPET-CT using FEOBV, MRI-scan, Cognitive assessment, Clinical assessment
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  8. Cholinergic System Changes in Dopa-Unresponsive Freezing of Gait in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
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  17. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Siamak Nejad-DavaraniRadiology, University of Michigan, Ann Arbor, MI, 48104, USA.
Robert A KoeppeRadiology, University of Michigan, Ann Arbor, MI, 48104, USA.
Roger L AlbinNeurology, University of Michigan, Ann Arbor, MI, 48104, USA.
Kirk A FreyRadiology, University of Michigan, Ann Arbor, MI, 48104, USA.
Martijn L T M MüllerRadiology, University of Michigan, Ann Arbor, MI, 48104, USA.
Nicolaas I BohnenRadiology, University of Michigan, Ann Arbor, MI, 48104, USA. nbohnen@umich.edu.ORCID http://orcid.org/0000-0003-0352-6414
University of Michigan · US

Funding

Tomography and Data AnalysisP01NS015655 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 1985 to 2012
$13.0M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
Cholinergic Interneurons in Tourette SyndromeR21NS088302 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2015
$427k
NINDS NIH HHS P01 NS015655NINDS NIH HHS P50 NS091856NINDS NIH HHS R01 NS070856NINDS NIH HHS R21 NS088302RRD VA I01 RX001631U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS015655U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS070856U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS088302U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS091856
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseLewy Body DiseaseBrainCholinergic AgentsDenervationHumansPositron-Emission TomographyCholinergic Agents

Identifiers

PMID30082840
PMCPMC6363916
OpenAlexW2887144058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.