ArticleNature communications2018
Differential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Cdk7 promotes neuritogenesis in cortical neurons and contributes to social behavior in mice.Cellular and molecular life sciences : CMLS · 2026Article
- Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p.eLife · 2025Article
- Inducible NMDA receptor knockdown reveals a maintenance phase in dendritic refinement of barrel cortex neurons.iScience · 2025Article
- Activity-dependent dendrite patterning in the postnatal barrel cortex.Frontiers in neural circuits · 2024Review
- Early-life maturation of the somatosensory cortex: sensory experience and beyond.Frontiers in neural circuits · 2024Review
- Article
- Thalamocortical control of cell-type specificity drives circuits for processing whisker-related information in mouse barrel cortex.Nature communications · 2023Article
- Rapid structural remodeling of peripheral taste neurons is independent of taste cell turnover.PLoS biology · 2023Article
- Review
- Optogenetic stimulation shapes dendritic trees of infragranular cortical pyramidal cells.Frontiers in cellular neuroscience · 2023Article
- Mesoscale calcium imagingFrontiers in neuroscience · 2023Review
- Targeted approaches to delineate neuronal morphology during early development.Frontiers in cellular neuroscience · 2023Review
- Spontaneous activity in whisker-innervating region of neonatal mouse trigeminal ganglion.Scientific reports · 2022Article
- Layers 3 and 4 Neurons of the Bilateral Whisker-Barrel Cortex.Neuroscience · 2022Article
- Editorial:Frontiers in neuroscience · 2022Article
- NMDA Receptor Enhances Correlation of Spontaneous Activity in Neonatal Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.Frontiers in cellular neuroscience · 2021Article
- Developmental Phase Transitions in Spatial Organization of Spontaneous Activity in Postnatal Barrel Cortex Layer 4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Drosophila miR-87 promotes dendrite regeneration by targeting the transcriptional repressor Tramtrack69.PLoS genetics · 2020Article
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3 authors.
Funding
Abstract
Proper neuronal circuit function relies on precise dendritic projection, which is established through activity-dependent refinement during early postnatal development. Here we revealed dynamics of dendritic refinement in the mammalian brain by conducting long-term imaging of the neonatal mouse barrel cortex. By "retrospective" analyses, we identified "prospective" barrel-edge spiny stellate (SS) neurons in early neonates, which had an apical dendrite and primitive basal dendrites (BDs). These neurons retracted the apical dendrite gradually and established strong BD orientation bias through continuous "dendritic tree" turnover. A greater chance of survival was given to BD trees emerged in the barrel-center side, where thalamocortical axons (TCAs) cluster. When the spatial bias of TCA inputs to SS neurons was lost, BD tree turnover was suppressed, and most BD trees became stable and elaborated mildly. Thus, barrel-edge SS neurons could establish the characteristic BD projection pattern through differential dynamics of dendritic trees induced by spatially biased inputs.
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