ArticleScientific reports2018
Bidirectional association between gastroesophageal reflux disease and depression: Two different nested case-control studies using a national sample cohort.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Benign Paroxysmal Positional Vertigo and the Increased Risk of Ischemic Stroke: A Nested Case-Control Study Using a National Cohort Sample.BioMed research international · 2021Trial
- Mendel randomization confirmed gastroesophageal reflux disease may increase the risk of mental disorders.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Article
- Depression and risk of gastro-oesophageal reflux disease (GERD): results from the UK Biobank study.BMC gastroenterology · 2026Article
- Vitamin D3 ameliorates inflammation and autonomic dysfunction in a rat model of reflux esophagitis via modulation of IL-6 and TNF-α.Scientific reports · 2025Article
- Disease clusters and their genetic determinants following a diagnosis of depression: analyses based on a novel three-dimensional disease network approach.Molecular psychiatry · 2025Article
- Multidimensional mechanisms and therapies underlying gastroesophageal reflux disease: focus on immunity, signaling pathways, and the microbiota-gut-brain axis.Frontiers in immunology · 2025Review
- A population-based study of familial coaggregation and shared genetic etiology of psychiatric and gastrointestinal disorders.Communications medicine · 2024Article
- Evaluation of the impact of oesophageal reflux disease on muscle fatigue.European journal of translational myology · 2024Article
- The impact of Renin-Angiotensin System Inhibitors on bone fracture risk: a nationwide nested case-control study.BMC musculoskeletal disorders · 2024Article
- Prevalence and risk factors of gastroesophageal reflux disease in Iran: A cross-sectional analysis from the PERSIAN cohort.PloS one · 2024Article
- Association of depression with gastroesophageal reflux disease, and the mediating role of risk factors: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Association of Tumor Necrosis Factor Inhibitors with the Risk of Nontuberculous Mycobacterial Infection in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study.Journal of clinical medicine · 2023Article
- Depression Promotes Gastroesophageal Reflux Disease: New Evidence Based on Mendelian Randomization.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Initial assessment of medical post-traumatic stress among patients with chronic esophageal diseases.Neurogastroenterology and motility · 2023Article
- Association between gastroesophageal reflux disease and stroke: a bidirectional Mendelian randomization study.Frontiers in neurology · 2023Article
- Shift work and risk of incident gastroesophageal reflux disease: the association and mediation.Frontiers in public health · 2023Article
- Major depressive disorder plays a vital role in the pathway from gastroesophageal reflux disease to chronic obstructive pulmonary disease: a Mendelian randomization study.Frontiers in genetics · 2023Article
- Correlation of Anxiety and Depression to the Development of Gastroesophageal Disease in the Younger Population.Cureus · 2022Review
- COVID-19 vaccine hesitancy between teachers and students in a college, a cross-sectional study in China.Human vaccines & immunotherapeutics · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
The purpose of this study is to evaluate the associations between gastroesophageal reflux disease (GERD) and depression using a national sample cohort of the Korean population. Data were collected from individuals ≥20 years old in the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2013. We designed two different nested case-control studies. In study I, 60,957 participants with depression were matched at a 1:4 ratio with 243,828 controls, and their previous histories of GERD were analyzed. In study II, 133,089 participants with GERD were matched at a 1:2 ratio with 266,178 controls, and their previous histories of depression were analyzed. Crude and adjusted odds ratios (ORs) were analyzed using unconditional logistic regression analyses, and 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to age and sex. The adjusted OR for GERD was 2.01 (95% CI = 1.96-2.07) in the patients with depression (study I). The adjusted OR for depression was 1.48 (95% CI = 1.43-1.52) in the patients with GERD (study II). The results of the subgroup analyses were consistent. GERD and depression displayed bidirectional associations.
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