ArticleScientific reports2018
Identification of candidate UDP-glycosyltransferases involved in protopanaxadiol-type ginsenoside biosynthesis in Panax ginseng.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 65 citations in OpenAlex.
- Comprehensive Genome Identification of theBiology · 2026Article
- Ginsenosides in the Root Exudates of Ginseng Infected with Rusty Root Rot Improve the Infectivity of PathogenicMicroorganisms · 2026Article
- Comprehensive Candidate Gene for Ginsenoside Rg1 Biosynthesis: Identification, Systematic Analysis, and Verification.Plants (Basel, Switzerland) · 2026Article
- Structure-Based Pipeline for Plant Enzymes: Pilot Study Identifying Novel Ginsenoside Biosynthetic UGTs.Biotech (Basel (Switzerland)) · 2025Article
- Transcriptome-wide identification and systematic analysis of the Retrotransposon genes and their roles in ginsenoside biosynthesis in Panax ginseng.BMC plant biology · 2025Article
- Identification ofPlants (Basel, Switzerland) · 2024Article
- Identification and analysis of UGT genes associated with triterpenoid saponin in soapberry (Sapindus mukorossi Gaertn.).BMC plant biology · 2024Article
- Functional Identification ofInternational journal of molecular sciences · 2024Article
- Mass spectrometry-based ginsenoside profiling: Recent applications, limitations, and perspectives.Journal of ginseng research · 2024Review
- Transcriptome-Wide Identification and Integrated Analysis of aPlants (Basel, Switzerland) · 2024Article
- Carvacrol as a Stimulant of the Expression of Key Genes of the Ginsenoside Biosynthesis Pathway and Its Effect on the Production of Ginseng Saponins inInternational journal of molecular sciences · 2024Article
- Ginsenoside Rc: A potential intervention agent for metabolic syndrome.Journal of pharmaceutical analysis · 2023Review
- Protopanaxadiol-Enriched Rice Extracts Suppressed Oxidative and Melanogenic Activities in Melan-a Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Comparative transcriptome and metabolome analyses of fourJournal of ginseng research · 2023Article
- Genes and Regulatory Mechanisms for Ginsenoside Biosynthesis.Journal of plant biology = Singmul Hakhoe chi · 2023Review
- Transcriptome and Phenotype Integrated Analysis Identifies Genes Controlling Ginsenoside Rb1 Biosynthesis and Reveals Their Interactions in the Process inInternational journal of molecular sciences · 2022Article
- Identification of key genes controlling soluble sugar and glucosinolate biosynthesis in Chinese cabbage by integrating metabolome and genome-wide transcriptome analysis.Frontiers in plant science · 2022Article
- A comparative phytochemical study of nine Lauraceae species by using chemometric data analysis.PloS one · 2022Article
- Genomic-Wide Identification and Characterization of the Uridine Diphosphate Glycosyltransferase Family inPlants (Basel, Switzerland) · 2021Article
- Optimization of Protein Isolation and Label-Free Quantitative Proteomic Analysis in Four Different Tissues of Korean Ginseng.Plants (Basel, Switzerland) · 2021Article
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13 authors at 2 institutions in 2 countries.
Funding
Abstract
Ginsenosides are dammarane-type or triterpenoidal saponins that contribute to the various pharmacological activities of the medicinal herb Panax ginseng. The putative biosynthetic pathway for ginsenoside biosynthesis is known in P. ginseng, as are some of the transcripts and enzyme-encoding genes. However, few genes related to the UDP-glycosyltransferases (UGTs), enzymes that mediate glycosylation processes in final saponin biosynthesis, have been identified. Here, we generated three replicated Illumina RNA-Seq datasets from the adventitious roots of P. ginseng cultivar Cheongsun (CS) after 0, 12, 24, and 48 h of treatment with methyl jasmonate (MeJA). Using the same CS cultivar, metabolomic data were also generated at 0 h and every 12-24 h thereafter until 120 h of MeJA treatment. Differential gene expression, phylogenetic analysis, and metabolic profiling were used to identify candidate UGTs. Eleven candidate UGTs likely to be involved in ginsenoside glycosylation were identified. Eight of these were considered novel UGTs, newly identified in this study, and three were matched to previously characterized UGTs in P. ginseng. Phylogenetic analysis further asserted their association with ginsenoside biosynthesis. Additionally, metabolomic analysis revealed that the newly identified UGTs might be involved in the elongation of glycosyl chains of ginsenosides, especially of protopanaxadiol (PPD)-type ginsenosides.
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