ArticleScientific reports2018
Characterization of LE3 and LE4, the only lytic phages known to infect the spirochete Leptospira.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Leptospira and Leptospirosis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Isolation, Purification, and Characterization of Leptophages.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Bioinformatic Identification of CRISPR-Cas Systems inPathogens (Basel, Switzerland) · 2025Article
- Article
- Evolutionary insights into the emergence of virulent Leptospira spirochetes.PLoS pathogens · 2024Article
- Comprehensive Analysis of Antiphage Defense Mechanisms: Serovar-Specific Patterns.Antibiotics (Basel, Switzerland) · 2024Article
- ExploringMicroorganisms · 2024Article
- Between Centralization and Fragmentation: The Past, Present, and Future of Phage Collections.PHAGE (New Rochelle, N.Y.) · 2024Review
- Current treatment options for leptospirosis: a mini-review.Frontiers in microbiology · 2024Review
- Complete Genome Sequencing ofPathogens (Basel, Switzerland) · 2021Article
- Bacteriophage infection ofMicrobiology (Reading, England) · 2021Article
- Comparative Genomic Analysis and a Novel Set of Missense Mutation of theFrontiers in microbiology · 2021Article
- Leptospira interrogans Retains Direct Virulence After Long Starvation in Water.Current microbiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptospira is a phylogenetically unique group of bacteria, and includes the causative agents of leptospirosis, the most globally prevalent zoonosis. Bacteriophages in Leptospira are largely unexplored. To date, a genomic sequence is available for only one temperate leptophage called LE1. Here, we sequenced and analysed the first genomes of the lytic phages LE3 and LE4 that can infect the saprophyte Leptospira biflexa using the lipopolysaccharide O-antigen as receptor. Bioinformatics analysis showed that the 48-kb LE3 and LE4 genomes are similar and contain 62% genes whose function cannot be predicted. Mass spectrometry led to the identification of 21 and 23 phage proteins in LE3 and LE4, respectively. However we did not identify significant similarities with other phage genomes. A search for prophages close to LE4 in the Leptospira genomes allowed for the identification of a related plasmid in L. interrogans and a prophage-like region in the draft genome of a clinical isolate of L. mayottensis. Long-read whole genome sequencing of the L. mayottensis revealed that the genome contained a LE4 phage-like circular plasmid. Further isolation and genomic comparison of leptophages should reveal their role in the genetic evolution of Leptospira.
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