Evidence map›Paper›PMID 30082509›Full record

ArticleActa crystallographica. Section D, Structural biology2018

Phosphoramidon inhibits the integral membrane protein zinc metalloprotease ZMPSTE24.

Brandon R Goblirsch, Buenafe T Arachea, Daniel J Councell, Michael C Wiener

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brandon R GoblirschDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908-0886, USA.
Buenafe T AracheaDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908-0886, USA.
Daniel J CouncellDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908-0886, USA.
Michael C WienerDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908-0886, USA.
University of Virginia · US

Funding

Structure and Function of the CaaX Protease Ste24pR01GM108612 · NIGMS · UNIVERSITY OF VIRGINIA · PI WIENER, MICHAEL · 2014 to 2017
$1.6M
NCI NIH HHS ACB-12002NIGMS NIH HHS AGM-12006NIGMS NIH HHS R01 GM108612NIH HHS R01GM108612U.S. Department of Energy, Office of Science DE-AC02-06CH11357
6 · The paper itself

Abstract

The integral membrane protein zinc metalloprotease ZMPSTE24 possesses a completely novel structure, comprising seven long kinked transmembrane helices that encircle a voluminous 14 000 Å

Indexed as

AnimalsBinding, CompetitiveCrystallography, X-RayEnzyme InhibitorsGlycopeptidesHumansInhibitory Concentration 50Membrane ProteinsMetalloendopeptidasesMolecular StructureProtein BindingSolubilityEnzyme InhibitorsGlycopeptidesMembrane ProteinsMetalloendopeptidasesphosphoramidonZMPSTE24 protein, humanphosphoramidonzinc metalloproteaseZMPSTE24

Identifiers

PMID30082509
PMCPMC6079626
OpenAlexW2884970544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.