Evidence map›Paper›PMID 30082483›Full record

ArticleMolecular cancer research : MCR2018

Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer.

Sun Young Yim, Jae-Jun Shim, Ji-Hyun Shin, Yun Seong Jeong, Sang-Hee Kang, Sang-Bae Kim, Young Gyu Eun, Dong Jin Lee, Elizabeth A Conner, Valentina M Factor and 4 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Molecular cancer research : MCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Proteomic analysis of DEN and CClScientific reports · 2024
    Article
  5. Review
  6. Translational cancer research · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Sun Young Yim *Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jae-Jun Shim *Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0003-2497-8663
Ji-Hyun Shin *Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Yun Seong JeongDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Sang-Hee KangDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-6097-8831
Sang-Bae KimDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Young Gyu EunDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0003-4081-5207
Dong Jin LeeDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Elizabeth A ConnerLaboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Valentina M FactorLaboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
David D MooreDepartment of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
Randy L JohnsonDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Snorri S ThorgeirssonLaboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Ju-Seog LeeDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. jlee@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USNational Institutes of Health · USBaylor College of Medicine · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
CCR Genomics CoreZICBC011623 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CONNER, ELIZABETH · 2015 to 2025
$20.5M
DEVELOPMENT AND VALIDATION OF PROGNOSTIC MODEL FOR GASTRIC CANCERR01CA150229 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LEE, JU-SEOG · 2010 to 2013
$1.1M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA150229
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a heterogeneous disease. Mouse models are commonly used as preclinical models to study hepatocarcinogenesis, but how well these models recapitulate molecular subtypes of human HCC is unclear. Here, integration of genomic signatures from molecularly and clinically defined human HCC (

Indexed as

AnimalsCarcinoma, HepatocellularDisease Models, AnimalGenomicsHumansLiver NeoplasmsLiver Neoplasms, ExperimentalMicePrognosis

Identifiers

PMID30082483
PMCPMC6431260
OpenAlexW2886455341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.