Evidence map›Paper›PMID 30082464›Full record

ReviewCold Spring Harbor perspectives in biology2019

Stress Granules and Processing Bodies in Translational Control.

Pavel Ivanov, Nancy Kedersha, Paul Anderson

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 313 papers.

0numbers the graph read from it
0cells of the map it votes in
313citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

313 citing papers in PubMed, 480 citations in OpenAlex.

  1. Article
  2. Article
  3. The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026
    Review
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  14. The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer.Journal of cellular and molecular medicine · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

253 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Pavel IvanovDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Nancy KedershaDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Paul AndersonDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Brigham and Women's Hospital · USHarvard University · US

Funding

Cellular Stress Response MechanismsR35GM126901 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2018 to 2022
$2.9M
Biology of RNA G-quadruplexesR01GM126150 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2019 to 2023
$1.9M
Stress granules and cell signalingR01GM111700 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2014 to 2017
$1.3M
Mechanisms of tiRNA-induced translational controlR01GM121410 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2017 to 2018
$710k
G-quadruplex Structures as Targets and Tools in ALSR21NS094918 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2015 to 2016
$488k
NIGMS NIH HHS R01 GM111700NIGMS NIH HHS R01 GM121410NIGMS NIH HHS R01 GM126150NIGMS NIH HHS R35 GM126901NINDS NIH HHS R21 NS094918
6 · The paper itself

Abstract

Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA granules that dynamically sequester translationally inactive messenger ribonucleoprotein particles (mRNPs) into compartments that are distinct from the surrounding cytoplasm. mRNP remodeling, silencing, and/or storage involves the dynamic partitioning of closed-loop polyadenylated mRNPs into SGs, or the sequestration of deadenylated, linear mRNPs into PBs. SGs form when stress-activated pathways stall translation initiation but allow elongation and termination to occur normally, resulting in a sudden excess of mRNPs that are spatially condensed into discrete foci by protein:protein, protein:RNA, and RNA:RNA interactions. In contrast, PBs can exist in the absence of stress, when specific factors promote mRNA deadenylation, condensation, and sequestration from the translational machinery. The formation and dissolution of SGs and PBs reflect changes in messenger RNA (mRNA) metabolism and allow cells to modulate the proteome and/or mediate life or death decisions during changing environmental conditions.

Indexed as

AnimalsCytoplasmic GranulesGene Expression RegulationProtein BiosynthesisRibonucleoproteinsmessenger ribonucleoproteinRibonucleoproteins

Identifiers

PMID30082464
PMCPMC6496347
OpenAlexW2885573416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.