Evidence map›Paper›PMID 30082431›Full record

ArticleThe Journal of general physiology2018

The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation.

Soumili Chatterjee, Rajan Vyas, Sreevatsa V Chalamalasetti, Indra D Sahu, Jérôme Clatot, Xiaoping Wan, Gary A Lorigan, Isabelle Deschênes, Sudha Chakrapani

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Calmodulin Interactions with Voltage-Gated Sodium Channels.International journal of molecular sciences · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Noncanonical Ion Channel Behaviour in Pain.International journal of molecular sciences · 2019
    Review
  18. Article
  19. Article
  20. Progress in understanding slow inactivation speeds up.The Journal of general physiology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Soumili ChatterjeeDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.
Rajan VyasDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.ORCID 0000-0003-0264-446X
Sreevatsa V ChalamalasettiDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.
Indra D SahuDepartment of Chemistry and Biochemistry, Miami University, Oxford, OH.
Jérôme ClatotHeart and Vascular Research Center, Department of Medicine, Case Western Reserve University, Cleveland, OH.
Xiaoping WanHeart and Vascular Research Center, Department of Medicine, Case Western Reserve University, Cleveland, OH.
Gary A LoriganDepartment of Chemistry and Biochemistry, Miami University, Oxford, OH.
Isabelle DeschênesDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.
Sudha ChakrapaniDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH sxc584@case.edu.ORCID 0000-0003-0722-2338
Case Western Reserve University · USMiami University · US

Funding

Sodium Channels and Cardiac ArrhythmiasR01HL094450 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE · 2010 to 2022
$4.0M
MOLECULAR MECHANISMS OF DESENSITIZATION AND DRUG MODULATION IN LIGAND-GATED ION CHANNELSR01GM108921 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI CHAKRAPANI, SUDHA · 2014 to 2018
$1.9M
NHLBI NIH HHS R01 HL094450NIGMS NIH HHS R01 GM108921
6 · The paper itself

Abstract

Slow inactivation in voltage-gated sodium channels (Na

Indexed as

Escherichia coliHEK293 CellsHumansProtein ConformationProtein DomainsSpectrum AnalysisVoltage-Gated Sodium ChannelsVoltage-Gated Sodium Channels

Identifiers

PMID30082431
PMCPMC6122925
OpenAlexW2887354287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.