ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Differentiable Processing of Objects, Associations, and Scenes within the Hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- From single scenes to extended scenarios: The role of the ventromedial prefrontal cortex in the construction of imagery-rich events.PloS one · 2026Article
- Reorganisation of Cortico-Hippocampal White Matter Pathways in Healthy Ageing: Evidence for Paradoxical Shifts in Structural Connectivity.bioRxiv : the preprint server for biology · 2025Article
- Semantic Dimensions Support the Cortical Representation of Object Memorability.Journal of cognitive neuroscience · 2025Article
- Similar processing of novelty in rat dorsal and intermediate CA1 despite differences in spatial tuning.bioRxiv : the preprint server for biology · 2025Article
- Disentangling structure-function relationships between the human hippocampus and the whole brain using track-weighted dynamic functional connectivity.bioRxiv : the preprint server for biology · 2025Article
- Preliminary study on changes in volume and functional connectivity of hippocampal subregions in patients with diabetic retinopathy.Brain imaging and behavior · 2025Article
- Stronger Short-Term Memory, Larger Hippocampi and Area V1 in People with High VVIQ Scores.Vision (Basel, Switzerland) · 2025Article
- Specialization of the human hippocampal long axis revisited.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Shaping the Space: A Role for the Hippocampus in Mental Imagery Formation.Vision (Basel, Switzerland) · 2025Review
- Missing images: autobiographical memory in Aphantasia and blindness.Frontiers in cognition · 2025Review
- New CRISPR/Cas9-based Fgfr2Journal of molecular medicine (Berlin, Germany) · 2024Article
- Changes in microstructural similarity of hippocampal subfield circuits in pathological cognitive aging.Brain structure & function · 2024Article
- Hippocampal subfields and their neocortical interactions during autobiographical memory.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Verbal recall in amnesia: Does scene construction matter?Neuropsychologia · 2023Article
- Single voxel autocorrelation uncovers gradients of temporal dynamics in the hippocampus and entorhinal cortex during rest and navigation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- New insights into anatomical connectivity along the anterior-posterior axis of the human hippocampus usingeLife · 2022Article
- What has vision science taught us about functional MRI?NeuroImage · 2022Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Article
- Category-specific memory encoding in the medial temporal lobe and beyond: the role of reward.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The hippocampus is known to be important for a range of cognitive functions, including episodic memory, spatial navigation, and thinking about the future. However, researchers have found it difficult to agree on the exact nature of this brain structure's contribution to cognition. Some theories emphasize the role of the hippocampus in associative processes. Another theory proposes that scene construction is its primary role. To directly compare these accounts of hippocampal function in human males and females, we devised a novel mental imagery paradigm where different tasks were closely matched for associative processing and mental construction, but either did or did not evoke scene representations, and we combined this with high-resolution functional MRI. The results were striking in showing that different parts of the hippocampus, along with distinct cortical regions, were recruited for scene construction or nonscene-evoking associative processing. The contrasting patterns of neural engagement could not be accounted for by differences in eye movements, mnemonic processing, or the phenomenology of mental imagery. These results inform conceptual debates in the field by showing that the hippocampus does not seem to favor one type of process over another; it is not a story of exclusivity. Rather, there may be different circuits within the hippocampus, each associated with different cortical inputs, which become engaged depending on the nature of the stimuli and the task at hand. Overall, our findings emphasize the importance of considering the hippocampus as a heterogeneous structure, and that a focus on characterizing how specific portions of the hippocampus interact with other brain regions may promote a better understanding of its role in cognition.
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Registered trials
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