Evidence map›Paper›PMID 30082414›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice.

Yang Yu, Takafumi Shintani, Yasushi Takeuchi, Takuji Shirasawa, Masaharu Noda

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yang YuDivision of Molecular Neurobiology, National Institute for Basic Biology, Okazaki 444-8787, Japan.
Takafumi ShintaniDivision of Molecular Neurobiology, National Institute for Basic Biology, Okazaki 444-8787, Japan, madon@nibb.ac.jp shin@nibb.ac.jp.
Yasushi TakeuchiSchool of Life Science, Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8787, Japan, and.
Takuji ShirasawaShirasawa Anti-Aging Medical Institute, Tokyo 113-0033, Japan.
Masaharu NodaDivision of Molecular Neurobiology, National Institute for Basic Biology, Okazaki 444-8787, Japan, madon@nibb.ac.jp shin@nibb.ac.jp.ORCID 0000-0002-3796-524X
National Institute for Basic Biology · JPThe Graduate University for Advanced Studies, SOKENDAI · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eph receptors play pivotal roles in the axon guidance of retinal ganglion cells (RGCs) at the optic chiasm and the establishment of the topographic retinocollicular map. We previously demonstrated that protein tyrosine phosphatase receptor type O (PTPRO) is specifically involved in the control of retinotectal projections in chicks through the dephosphorylation of EphA and EphB receptors. We subsequently revealed that all the mouse R3 subfamily members (PTPRB, PTPRH, PTPRJ, and PTPRO) of the receptor protein tyrosine phosphatase (RPTP) family inhibited Eph receptors as their substrates in cultured mammalian cells. We herein investigated the functional roles of R3 RPTPs in the projection of mouse retinal axon of both sexes.

Indexed as

AnimalsAxonsCells, CulturedFemaleMaleMice, Inbred C57BLMice, KnockoutProto-Oncogene Proteins c-ablReceptor-Like Protein Tyrosine Phosphatases, Class 3Receptors, Eph FamilyRetinaRetinal Ganglion CellsSuperior ColliculiUp-RegulationVisual PathwaysProto-Oncogene Proteins c-ablPtprj protein, mouseReceptor-Like Protein Tyrosine Phosphatases, Class 3Receptors, Eph Familyc-AblEph receptorsPTPRJPTPROR3 RPTPstopographic maps

Identifiers

PMID30082414
PMCPMC6596168
OpenAlexW2887574577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.