Evidence map›Paper›PMID 30082411›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes.

Boryana Petrova, Keke Liu, Caiping Tian, Maiko Kitaoka, Elizaveta Freinkman, Jing Yang, Terry L Orr-Weaver

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Declining ribosome function limits oocyte longevity.bioRxiv : the preprint server for biology · 2026
    Article
  2. Heat stress drives opposing redox shifts in temperate versus tropicalbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Translational Fidelity Decline in the Aging Oocyte and Embryo Development.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Ribosome Assembly and Repair.Annual review of cell and developmental biology · 2024
    Review
  12. Article
  13. Article
  14. Redox mechanisms of environmental toxicants on male reproductive function.Frontiers in cell and developmental biology · 2024
    Review
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Boryana PetrovaWhitehead Institute for Biomedical Research, Cambridge, MA 02142.
Keke LiuState Key Laboratory of Proteomics, National Center for Protein Sciences, Beijing Proteome Research Center, Beijing Institute of Lifeomics, 102206 Beijing, China.
Caiping TianState Key Laboratory of Proteomics, National Center for Protein Sciences, Beijing Proteome Research Center, Beijing Institute of Lifeomics, 102206 Beijing, China.
Maiko KitaokaWhitehead Institute for Biomedical Research, Cambridge, MA 02142.
Elizaveta FreinkmanWhitehead Institute for Biomedical Research, Cambridge, MA 02142.
Jing YangState Key Laboratory of Proteomics, National Center for Protein Sciences, Beijing Proteome Research Center, Beijing Institute of Lifeomics, 102206 Beijing, China; yangjing54@hotmail.com weaver@wi.mit.edu.ORCID 0000-0001-8486-273X
Terry L Orr-WeaverWhitehead Institute for Biomedical Research, Cambridge, MA 02142; yangjing54@hotmail.com weaver@wi.mit.edu.ORCID 0000-0002-7934-111X

Funding

Producing, provisioning, and protecting the egg: Regulation of DNA replication, mRNA translation, and proteolysis for the transition from oocyte to embryoR35GM118098 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI ORR-WEAVER, TERRY L. · 2016 to 2018
$2.0M
NIGMS NIH HHS R35 GM118098
6 · The paper itself

Abstract

The metabolic and redox state changes during the transition from an arrested oocyte to a totipotent embryo remain uncharacterized. Here, we applied state-of-the-art, integrated methodologies to dissect these changes in

Indexed as

AnimalsCell CycleCysteineDrosophila melanogasterDrosophila ProteinsEmbryonic DevelopmentEmbryo, NonmammalianMembrane ProteinsMutationOocytesOxidation-ReductionThioredoxinsCysteineDHD protein, DrosophilaDrosophila ProteinsMembrane ProteinsThioredoxinschemical proteomicsDrosophilameiosismetabolomicsthiol reactivity profiling

Identifiers

PMID30082411
PMCPMC6112717

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.