Evidence map›Paper›PMID 30082397›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Mass spider silk production through targeted gene replacement in

Jun Xu, Qinglin Dong, Ye Yu, Baolong Niu, Dongfeng Ji, Muwang Li, Yongping Huang, Xin Chen, Anjiang Tan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Spider Eye Development Editing and Silk Fiber Engineering Using CRISPR-Cas.Angewandte Chemie (International ed. in English) · 2025
    Article
  11. High-yield spidroin mimics for bioinspired fibers via computational design.Frontiers in bioengineering and biotechnology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jun XuKey Laboratory of Insect Developmental and Evolutionary Biology, Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China.
Qinglin DongState Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
Ye YuKey Laboratory of Insect Developmental and Evolutionary Biology, Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China.
Baolong NiuSericultural Research Institute, Zhejiang Academy of Agricultural Sciences, 310021 Hangzhou, China.
Dongfeng JiSericultural Research Institute, Zhejiang Academy of Agricultural Sciences, 310021 Hangzhou, China.
Muwang LiSericultural Research Institute, Jiangsu University of Science and Technology, 212018 Zhenjiang, Jiangsu, China.
Yongping HuangKey Laboratory of Insect Developmental and Evolutionary Biology, Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China.
Xin ChenState Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
Anjiang TanKey Laboratory of Insect Developmental and Evolutionary Biology, Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China; ajtan01@sibs.ac.cn.
Center for Excellence in Molecular Plant Sciences · CNSericultural Research Institute · CNFudan University · CNChinese Academy of Sciences · CN

Funding

Investigation of metabolites related to manganese exposureF31ES027304 · NIEHS · UNIVERSITY OF WASHINGTON · PI BAKER, MARISSA GAYL · 2016 to 2017
$61k
NIEHS NIH HHS 27304C2054
6 · The paper itself

Abstract

Spider silk is one of the best natural fibers and has superior mechanical properties. However, the large-scale harvesting of spider silk by rearing spiders is not feasible, due to their territorial and cannibalistic behaviors. The silkworm,

Indexed as

Animals, Genetically ModifiedBombyxFibroinsGenetic EngineeringAnimalsSpidersFibroinsspidroin 1Bombyx morigenome editingspider silkTALEN

Identifiers

PMID30082397
PMCPMC6126722
OpenAlexW2886644202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.