Evidence map›Paper›PMID 30082385›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca

Kimberli J Kamer, Yasemin Sancak, Yevgenia Fomina, Joshua D Meisel, Dipayan Chaudhuri, Zenon Grabarek, Vamsi K Mootha

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 70 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Mitochondrial Calcium Signaling in Hepatocyte Health and Disease.Cold Spring Harbor perspectives in biology · 2026
    Review
  6. Metal Ion Signaling in Biomedicine.Chemical reviews · 2025
    Review
  7. Review
  8. Review
  9. Calcium signaling in mitochondrial intermembrane space.Biochemical Society transactions · 2024
    Review
  10. Article
  11. Article
  12. Increased cytotoxicity of PbEnvironmental science. Processes & impacts · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. MICU1 occludes the mitochondrial calcium uniporter in divalent-free conditions.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kimberli J KamerDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0001-8728-7793
Yasemin SancakHoward Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114.
Yevgenia FominaHoward Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114.
Joshua D MeiselHoward Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114.
Dipayan ChaudhuriNora Eccles Harrison Cardiovascular Research and Training Institute, Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112.ORCID 0000-0003-0605-7334
Zenon GrabarekHoward Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114; grabarek@molbio.mgh.harvard.edu vamsi@hms.harvard.edu.
Vamsi K MoothaHoward Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114; grabarek@molbio.mgh.harvard.edu vamsi@hms.harvard.edu.
Howard Hughes Medical Institute · USBroad Institute · USUniversity of Utah · US

Funding

Molecular Architecture Of The Mitochondrial Calcium UniporterR01HL130143 · NHLBI · HARVARD MEDICAL SCHOOL · PI CHOU, JAMES JEIWEN, MOOTHA, VAMSI KRISHNA · 2017 to 2020
$3.2M
Structural basis for mitochondrial calcium uniporter functionR00HL124070 · NHLBI · UNIVERSITY OF UTAH · PI CHAUDHURI, DIPAYAN · 2016 to 2018
$747k
Howard Hughes Medical InstituteNHLBI NIH HHS R00 HL124070NHLBI NIH HHS R01 HL130143
6 · The paper itself

Abstract

The mitochondrial uniporter is a Ca

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsHEK293 CellsHumansIon TransportK562 CellsManganeseMitochondrial Membrane Transport ProteinsCaenorhabditis elegans ProteinsCalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsManganeseMICU1 protein, humanmitochondrial calcium uniporterMitochondrial Membrane Transport ProteinscalciumEF handmanganeseneurodegenerationselectivity

Identifiers

PMID30082385
PMCPMC6112746
OpenAlexW2885630790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.