Evidence map›Paper›PMID 30082367›Full record

ArticleBMJ open2018

The HARMONIC trial: study protocol for a randomised controlled feasibility trial of Shaping Healthy Minds-a modular transdiagnostic intervention for mood, stressor-related and anxiety disorders in adults.

Melissa Black, Caitlin Hitchcock, Anna Bevan, Cliodhna O Leary, James Clarke, Rachel Elliott, Peter Watson, Louise LaFortune, Sarah Rae, Simon Gilbody and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03143634 (The Modular Protocol for Mental Health), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03143634 phase1 / phase2completednot on this map

The Modular Protocol for Mental Health (MPMH): A Pilot Randomised Clinical Trial of a Transdiagnostic Psychological Treatment for Mood and Anxiety Disorders in Adults

TypeinterventionalSponsorMedical Research Council Cognition and Brain Sciences UnitRan2017 to 2020Enrolled43ConditionsMajor Depressive Disorder, Generalized Anxiety Disorder, Posttraumatic Stress Disorder, Social Anxiety DisorderArmsThe Modular Protocol for Mental Health, Treatment-as-usual
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): III. Emotional dysfunction superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Melissa BlackMedical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1450-1140
Caitlin HitchcockMedical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2435-0713
Anna BevanMedical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Cliodhna O LearyMedical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
James ClarkeCambridgeshire and Peterborough NHS Foundation Trust, National Health Service, Fulbourn, UK.
Rachel ElliottMedical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Peter WatsonMedical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Louise LaFortuneCambridge Institute of Public Health, University of Cambridge, Cambridge, UK.
Sarah RaeCambridgeshire and Peterborough NHS Foundation Trust, National Health Service, Fulbourn, UK.
Simon GilbodyDepartment of Health Sciences, University of York, York, UK.
Willem KuykenDepartment of Psychiatry, University of Oxford, Oxford, UK.
David JohnstonMedical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Jill M NewbySchool of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
Tim DalgleishMedical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.

Funding

Department of Health PB-PG-0214-33072Medical Research Council MC_UU_00005/4
6 · The paper itself

Abstract

introductionAnxiety, mood and trauma-related disorders are common, affecting up to 20% of adults. Many of these individuals will experience symptoms of more than one disorder as diagnostically defined. However, most psychological treatments focus on individual disorders and are less effective for those who experience comorbid disorders. The Healthy and Resilient Mind Programme: Building Blocks for Mental Wellbeing (HARMONIC) trial introduces a novel transdiagnostic intervention ( METHODS/ANALYSIS: We outline a patient-level two-arm randomised controlled trial (HARMONIC) that compares ETHICS AND DISSEMINATION: This trial protocol has been approved by the Health Research Authority of the NHS of the UK (East of England, Reference: 16/EE/0095). We anticipate that trial findings will inform future revisions of clinical guidelines for numerous forms of mood, anxiety and stressor-related disorders. Findings will be disseminated broadly via peer-reviewed empirical journal articles, conference presentations, clinical workshops and a trial website.

trial registrationNCT03143634; Pre-results.

Indexed as

AdultAnxiety DisordersFeasibility StudiesHumansMood DisordersObsessive-Compulsive DisorderPatient Acceptance of Health CarePatient Reported Outcome MeasuresRandomized Controlled Trials as TopicResearch DesignStress Disorders, TraumaticSymptom Assessmentanxietycommon mental health problemsdepressionposttraumatic stress disordertransdiagnostic

Identifiers

PMID30082367
PMCPMC6078277

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.