Evidence map›Paper›PMID 30082342›Full record

ArticleBMJ open2018

Protocol for the study of cervical cancer screening technologies in HIV-infected women living in Rwanda.

Gad Murenzi, Jean-Claude Dusingize, Theogene Rurangwa, Jean d'Amour Sinayobye, Athanase Munyaneza, Anthere Murangwa, Thierry Zawadi, Tiffany Hebert, Pacifique Mugenzi, Adebola Adedimeji and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Gad MurenziRwanda Military Hospital, Kigali, Rwanda.
Jean-Claude DusingizeRwanda Military Hospital, Kigali, Rwanda.
Theogene RurangwaRwanda Military Hospital, Kigali, Rwanda.
Jean d'Amour SinayobyeRwanda Military Hospital, Kigali, Rwanda.
Athanase MunyanezaRwanda Military Hospital, Kigali, Rwanda.
Anthere MurangwaRwanda Military Hospital, Kigali, Rwanda.
Thierry ZawadiRwanda Military Hospital, Kigali, Rwanda.
Tiffany HebertAlbert Einstein College of Medicine, Bronx, New York, USA.
Pacifique MugenziRwanda Military Hospital, Kigali, Rwanda.
Adebola AdedimejiAlbert Einstein College of Medicine, Bronx, New York, USA.
Leon MutesaRwanda Military Hospital, Kigali, Rwanda.
Kathryn AnastosAlbert Einstein College of Medicine, Bronx, New York, USA.
Philip E CastleAlbert Einstein College of Medicine, Bronx, New York, USA.
Rwanda Military Hospital · RWAlbert Einstein College of Medicine · US

Funding

Shared ResourcesU54CA190163 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ANASTOS, KATHRYN M., CASTLE, PHILIP E · 2014 to 2019
$4.1M
NCI NIH HHS U54 CA190163
6 · The paper itself

Abstract

introductionThe optimal method(s) for screening HIV-infected women, especially for those living in sub-Saharan Africa, for cervical precancer and early cancer has yet to be established. METHODS AND ANALYSIS: A convenience sample of >5000 Rwandan women, ages 30-54 years and living with HIV infection, is being consented and enroled into a cross-sectional study of cervical cancer screening strategies. Participants are completing an administered short risk factor questionnaire and being screened for high-risk human papillomavirus (hrHPV) using the Xpert HPV assay (Cepheid, Sunnyvale, California, USA), unaided visual inspection after acetic acid (VIA) and aided VIA using the Enhanced Visual Assessment (EVA) system (Mobile ODT, Tel Aviv, Israel). Women positive for hrHPV and/or by unaided VIA undergo colposcopy, which includes the collection of two cervical specimens prior to undergoing a four-quadrant microbiopsy protocol. The colposcopy-collected specimens are being tested by dual immunocytochemical staining for p16 ETHICS AND DISSEMINATION: The protocol was approved by local and institutional review boards for human subjects research. At the completion of the study, results will be disseminated to the scientific community through peer-reviewed publication and to the Rwandan stakeholders through an external advisory panel.

Indexed as

Clinical ProtocolsResearch DesignAdultColposcopyCross-Sectional StudiesDNA, ViralEarly Detection of CancerFemaleGenotypeHIV InfectionsHumansMiddle AgedOncogene Proteins, ViralPapillomaviridaePapillomavirus InfectionsRwandaDNA, ViralOncogene Proteins, Viralcervical cancercervical intraepithelial neoplasiagynaecologyhuman papillomavirus (hpv)

Identifiers

PMID30082342
PMCPMC6078254
OpenAlexW2885851190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.