Trial reportDiabetes care2018
Effects of Interrupting Sedentary Behavior With Short Bouts of Moderate Physical Activity on Glucose Tolerance in Children With Overweight and Obesity: A Randomized Crossover Trial.
Trial report in Diabetes care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Break It Up: A Study Evaluating Breaking Up Daily Sedentary Behavior in Youth
Testing the Efficacy of Multi-day Interruptions in Sedentary Behaviors on Metabolic, Cognitive, and Affective Outcomes in Youth at Risk for Type 2 Diabetes
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Acute effects of "exercise snacks" on postprandial glucose and insulin responses in populations at metabolic risk: a meta-analysis with exploratory meta-regression and vascular outcomes.Frontiers in endocrinology · 2026Pooled it
- Multiple Shorter High-Intensity Interval Exercise Sessions During the Day Result in Greater Energy Expenditure With Less Exertion Than a Longer Single Session: A Randomized Crossover Clinical Trial.European journal of sport science · 2025Trial
- Effects of interrupting daily sedentary behavior on children's glucose metabolism: A 6-day randomized controlled trial.Pediatric diabetes · 2022Trial
- The Effects of Interrupting Sitting Time on Affect and State Anxiety in Children of Healthy Weight and Overweight: A Randomized Crossover Trial.Pediatric exercise science · 2020Trial
- Accelerometer-based 24-h movement behaviours in children and adolescents with Down syndrome.European journal of pediatrics · 2026Article
- Accumulation patterns of sedentary and breaks and adiposity risk in Chinese children and adolescents: a latent profile analysis.BMC public health · 2025Article
- Design of a randomized controlled trial to test the efficacy of interrupting sitting on type 2 diabetes risk factors in children with overweight/obesity: The sedentary behavior study 3 protocol.Contemporary clinical trials · 2025Article
- Move less, spend more: the metabolic demands of short walking bouts.Proceedings. Biological sciences · 2024Article
- Perceived stress and associations between physical activity, sedentary time, and interstitial glucose in healthy adolescents.Physiology & behavior · 2024Article
- Physiology of sedentary behavior.Physiological reviews · 2023Review
- KLB and NOX4 expression levels as potential blood-based transcriptional biomarkers of physical activity in children.Scientific reports · 2023Article
- Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice.Environment international · 2023Article
- Article
- The bad rainbow of COVID-19 time: effects on glucose metabolism in children and adolescents with obesity and overweight.International journal of obesity (2005) · 2022Article
- Changes in sedentary behavior patterns during the transition from childhood to adolescence and their association with adiposity: a prospective study based on compositional data analysis.Archives of public health = Archives belges de sante publique · 2022Article
- Breaks in Sedentary Time and Cardiometabolic Markers in Adolescents.Arquivos brasileiros de cardiologia · 2021Article
- The impact of standing desks on cardiometabolic and vascular health.Vascular medicine (London, England) · 2021Article
- The Association of Different Sedentary Patterns and Health-Related Physical Fitness in Pre-schoolers.Frontiers in pediatrics · 2021Article
- Ambulatory hemodynamic patterns, obesity, and pulse wave velocity in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2020Article
- Classroom Active Breaks to Increase Children's Physical Activity: A Cross-Sectional Study in the Province of Naples, Italy.International journal of environmental research and public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 1 institution in 1 country.
Funding
Abstract
objectiveSedentary children have greater risk of developing abnormalities in glucose homeostasis. We investigated whether interrupting sedentary behavior (sitting) with very short periods of walking would improve glucose metabolism without affecting dietary intake in children with overweight or obesity. We hypothesized that interrupting sitting with short bouts of moderate-intensity walking would decrease insulin area under the curve (AUC) during an oral glucose tolerance test (OGTT) compared with uninterrupted sitting. RESEARCH DESIGN AND
methodsOverweight/obese (BMI ≥85th percentile) children 7-11 years of age underwent two experimental conditions in random order: prolonged sitting (3 h of continuous sitting) and interrupted sitting (3 min of moderate-intensity walking at 80% of ventilatory threshold every 30 min for 3 h). Insulin, C-peptide, and glucose were measured every 30 min for 3 h during an OGTT. Each session was followed by a buffet meal. Primary outcomes were differences in OGTT hormones and substrates and in buffet meal intake by condition.
resultsAmong 35 children with complete data, mixed-model results identified lower insulin and C-peptide in the interrupted condition (
conclusionsInterrupting sitting with brief moderate-intensity walking improved glucose metabolism without significantly increasing energy intake in children with overweight or obesity. Interrupting sedentary behavior may be a promising intervention strategy for reducing metabolic risk in such children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.