Evidence map›Paper›PMID 30082320›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses.

Sarang Tartey, Prajwal Gurung, Parimal Samir, Amanda Burton, Thirumala-Devi Kanneganti

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. CD47 haltsScience advances · 2023
    Article
  7. Review
  8. Neutrophilic Dermatoses: a Clinical Update.Current dermatology reports · 2022
    Review
  9. CARD9 Signaling, Inflammation, and Diseases.Frontiers in immunology · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. The Role of CARD9 Deficiency in Neutrophils.Mediators of inflammation · 2021
    Review
  14. Review
  15. Pyoderma gangrenosum.Nature reviews. Disease primers · 2020
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarang TarteyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105; and.ORCID 0000-0002-7957-9208
Prajwal GurungDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105; and.ORCID 0000-0002-7451-9433
Parimal SamirDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105; and.ORCID 0000-0001-7655-5713
Amanda BurtonDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105; and.
Thirumala-Devi KannegantiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105; and Thirumala-Devi.Kanneganti@StJude.org.ORCID 0000-0002-6395-6443
St. Jude Children's Research Hospital · USUniversity of Iowa · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Role of NLR Inflammasomes in Autoinflammatory Diseases and Host DefenseR01AR056296 · NIAMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2008 to 2022
$5.9M
The Non-Inflammasome NLRs in Immunity and Host defenseR01AI124346 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2016 to 2026
$5.8M
Inflammatory Caspases in Innate Immunity and InflammationR37AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2017 to 2026
$4.9M
NLR signaling in colitis and colorectal tumorigenesisR01CA163507 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2020
$3.5M
Inflammatory Caspases in Innate Immunity and InflammationR01AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2016
$2.2M
NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA163507NIAID NIH HHS R01 AI101935NIAID NIH HHS R01 AI124346NIAID NIH HHS R37 AI101935NIAMS NIH HHS R01 AR056296
6 · The paper itself

Abstract

Mice homozygous for the Y208N amino acid substitution in the carboxy terminus of SHP-1 (referred to as

Indexed as

Amino Acid SubstitutionAnimalsCARD Signaling Adaptor ProteinsDermatitisDisease Models, AnimalInflammationInterleukin-1alphaMiceMice, KnockoutMutation, MissenseNeutrophilsProtein Tyrosine Phosphatase, Non-Receptor Type 6Receptors, Interleukin-1Signal TransductionCard9 protein, mouseCARD Signaling Adaptor ProteinsInterleukin-1alphaProtein Tyrosine Phosphatase, Non-Receptor Type 6Ptpn6 protein, mouseReceptors, Interleukin-1

Identifiers

PMID30082320
PMCPMC6483079
OpenAlexW2887492487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.