Evidence map›Paper›PMID 30082048›Full record

ArticleThe Lancet. Planetary health2018

Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis.

Philip L Bulterys, Michelle A Bulterys, Koukeo Phommasone, Manophab Luangraj, Mayfong Mayxay, Sabine Kloprogge, Thyl Miliya, Manivanh Vongsouvath, Paul N Newton, Rattanaphone Phetsouvanh and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Planetary health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  12. Burkholderia pseudomallei and melioidosis.Nature reviews. Microbiology · 2024
    Review
  13. Article
  14. Genetic diversity, determinants, and dissemination ofbioRxiv : the preprint server for biology · 2023
    Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Philip L BulterysUCLA-Caltech Medical Scientist Training Program, David Geffen School of Medicine, Los Angeles, CA, USA; Molecular Biology Institute, Los Angeles, CA, USA; Department of Microbiology, Immunology, and Molecular Genetics, Los Angeles, CA, USA. Electronic address: pbulterys@mednet.ucla.edu.
Michelle A BulterysSchool of Public Health, University of Washington, Seattle, WA, USA.
Koukeo PhommasoneLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos.
Manophab LuangrajLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos.
Mayfong MayxayLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Faculty of Postgraduate Studies, University of Health Sciences, Ministry of Health, Vientiane, Laos.
Sabine KloproggeCambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia.
Thyl MiliyaCambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia.
Manivanh VongsouvathLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos.
Paul N NewtonLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Rattanaphone PhetsouvanhLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Christopher T FrenchDepartment of Microbiology, Immunology, and Molecular Genetics, Los Angeles, CA, USA; California NanoSystems Institute UCLA, Los Angeles, CA, USA.
Jeff F MillerMolecular Biology Institute, Los Angeles, CA, USA; Department of Microbiology, Immunology, and Molecular Genetics, Los Angeles, CA, USA; California NanoSystems Institute UCLA, Los Angeles, CA, USA.
Paul TurnerCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Cambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia.
David A B DanceLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit · LAAngkor Hospital for Children · KHCalifornia NanoSystems Institute · USUniversity of Oxford · GBCalifornia Institute of Technology · USCambodia-Oxford Medical Research Unit · KHLondon School of Hygiene & Tropical Medicine · GBUniversity of Washington · US

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Intercellular spread of Burkholderia and novel therapeutic strategiesF30AI118342 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BULTERYS, PHILIP L. · 2016 to 2018
$132k
NIAID NIH HHS F30 AI118342NIGMS NIH HHS T32 GM008042Wellcome TrustWellcome Trust 106698/Z/14/Z
6 · The paper itself

Abstract

backgroundBurkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies.

methodsWe examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between February, 2009, and December, 2013. We also examined local temperature, humidity, precipitation, visibility, and wind data for the corresponding time periods. We estimated the B pseudomallei incubation period by examining profile likelihoods for hypothetical exposure-to-presentation delays.

findings870 patients were diagnosed with melioidosis in Laos and 173 patients were diagnosed with melioidosis in Cambodia during the study periods. Melioidosis cases were significantly associated with humidity (p<0·0001), low visibility (p<0·0001), and maximum wind speeds (p<0·0001) in Laos, and humidity (p=0·010), rainy days (p=0·015), and maximum wind speed (p=0·0070) in Cambodia. Compared with adults, children were at significantly higher odds of infection during highly humid months (odds ratio 2·79, 95% CI 1·83-4·26). Lung and disseminated infections were more common during windy months. The maximum likelihood estimate of the incubation period was 1 week (95% CI 0-2).

interpretationThe results of this study demonstrate a significant seasonal burden of melioidosis among adults and children in Laos and Cambodia. Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for increased awareness among at-risk individuals, such as children.

fundingWellcome Trust.

Indexed as

ClimateWeatherAdultAgedAged, 80 and overBurkholderia pseudomalleiCambodiaChildChild, PreschoolCohort StudiesFemaleHumansIncidenceLaosLikelihood FunctionsMale

Identifiers

PMID30082048
PMCPMC6076299
OpenAlexW2886514492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.