Evidence map›Paper›PMID 30082022›Full record

ArticleeLife2018

Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance.

Kentarou Baba, Wataru Yoshida, Michinori Toriyama, Tadayuki Shimada, Colleen F Manning, Michiko Saito, Kenji Kohno, James S Trimmer, Rikiya Watanabe, Naoyuki Inagaki

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Weak and Tunable Adhesion-Clutch Drives Rapid Cell Migration and Glioblastoma Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Unraveling Axon Guidance during Axotomy and Regeneration.International journal of molecular sciences · 2021
    Review
  17. Forces to Drive Neuronal Migration Steps.Frontiers in cell and developmental biology · 2020
    Review
  18. Article
  19. Article
  20. Molecular basis of the functions of the mammalian neuronal growth cone revealed using new methods.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Kentarou BabaDivision of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan.
Wataru Yoshida *Division of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan.
Michinori Toriyama *Division of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan.
Tadayuki ShimadaDivision of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan.ORCID 0000-0001-7333-9847
Colleen F ManningDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, United States.
Michiko SaitoDivision of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan.ORCID 0000-0002-6678-2135
Kenji KohnoDivision of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan.ORCID 0000-0002-3503-6551
James S TrimmerDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, United States.ORCID 0000-0002-6117-3912
Rikiya WatanabeDepartment of Applied Chemistry, Graduate School of Engineering, University of Tokyo, Tokyo, Japan.
Naoyuki InagakiDivision of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan.ORCID 0000-0002-2664-9196
Nara Institute of Science and Technology · JPUniversity of California, Davis · USThe University of Tokyo · JP

Funding

Japan Agency for Medical Research and Development JP17gm0810011Japan Society for the Promotion of Science JP23370088Japan Society for the Promotion of Science JP25102010Japan Society for the Promotion of Science JP26290007
6 · The paper itself

Abstract

Growth cones navigate axonal projection in response to guidance cues. However, it is unclear how they can decide the migratory direction by transducing the local spatial cues into protrusive forces. Here we show that knockout mice of

Indexed as

ChemotaxisMechanotransduction, CellularActinsAnimalsAxon GuidanceCell AdhesionCells, CulturedEmbryo, MammalianGrowth ConesMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNetrin-1Neural Cell Adhesion Molecule L1p21-Activated KinasesActinsNerve Tissue ProteinsNetrin-1Neural Cell Adhesion Molecule L1Ntn1 protein, mousep21-Activated KinasesPak1 protein, mouseshootin 1 protein, mouseaxon guidancecell biologychemotaxisclutchgradient sensinggrowth conemouseneuroscienceratshootin1

Identifiers

PMID30082022
PMCPMC6080949
OpenAlexW2886217137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.