ArticleeLife2018
Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Tracing the patterns of HIV-1 transmission among people with different diagnosis status in Greece.Virus research · 2026Article
- Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics.Microorganisms · 2023Review
- Article
- Hepatitis B Virus Research in South Africa.Viruses · 2022Review
- Women in the European Virus Bioinformatics Center.Viruses · 2022Article
- Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular Carcinoma.Microorganisms · 2022Article
- Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1.Virus evolution · 2022Review
- Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide.PloS one · 2022Article
- Variable Proportions of Phylogenetic Clustering and Low Levels of Antiviral Drug Resistance among the Major HBV Sub-Genotypes in the Middle East and North Africa.Pathogens (Basel, Switzerland) · 2021Article
- Article
- Origins and Evolution of the Primate Hepatitis B Virus.Frontiers in microbiology · 2021Review
- Analysis of Hepatitis B Virus Genotype D in Greenland Suggests the Presence of a Novel Quasi-Subgenotype.Frontiers in microbiology · 2020Article
- Global and regional dispersal patterns of hepatitis B virus genotype E from and in Africa: A full-genome molecular analysis.PloS one · 2020Article
- Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.Polish journal of microbiology · 2019Article
- Article
- Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas.PloS one · 2019Article
- Genetic and Phenotypic Characterization of Cryphonectria hypovirus 1 from Eurasian Georgia.Viruses · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct their global phylogeny. Phylogeographic analysis was conducted by the reconstruction of ancestral states using the criterion of parsimony. The putative origin of genotype D was in North Africa/Middle East. HBV-D sequences form low levels of regional clustering for the Middle East and Southern Europe. In contrast, HBV-A sequences form two major clusters, the first including sequences mostly from sub-Saharan Africa, and the second including sequences mostly from Western and Central Europe. Conclusion: We observed considerable differences in the global dissemination patterns of HBV-D and HBV-A and different levels of monophyletic clustering in relation to the regions of prevalence of each genotype.
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