Evidence map›Paper›PMID 30081933›Full record

ArticleTrials2018

Educate, Nurture, Advise, Before Life Ends Comprehensive Heartcare for Patients and Caregivers (ENABLE CHF-PC): study protocol for a randomized controlled trial.

Rachel Wells, Macy L Stockdill, J Nicholas Dionne-Odom, Deborah Ejem, Kathryn L Burgio, Raegan W Durant, Sally Engler, Andres Azuero, Salpy V Pamboukian, Jose Tallaj and 4 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02505425 (Randomized Trial of ENABLE CHF-PC for Heart Failure Patients and Caregivers.), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02505425 nacompletednot on this map

Randomized Trial of ENABLE CHF-PC for Heart Failure Patients and Caregivers. (Comprehensive Heartcare For Patients and Caregivers)

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2015 to 2019Enrolled573ConditionsHeart FailureArmsBehavioral Support, Usual HF Care
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Advance care planning for adults with heart failure.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Investigating the impact of the COVID-19 pandemic on breast cancer clinicians' communication about sexual health.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  16. Article
  17. Article
  18. Self-care research: Where are we now? Where are we going?International journal of nursing studies · 2021
    Article
  19. Levosimendan Efficacy and Safety: 20 Years of SIMDAX in Clinical Use.Journal of cardiovascular pharmacology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Rachel WellsSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Macy L StockdillSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
J Nicholas Dionne-OdomSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Deborah EjemSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Kathryn L BurgioDepartment of Medicine, Division of Gerontology, Geriatrics, Palliative Care, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Raegan W DurantDepartment of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Sally EnglerSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Andres AzueroSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Salpy V PamboukianDepartment of Medicine, Division of Cardiovascular Diseases, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Jose TallajDepartment of Medicine, Division of Cardiovascular Diseases, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Keith M SwetzDepartment of Medicine, Division of Gerontology, Geriatrics, Palliative Care, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
Elizabeth KvaleDepartment of Medicine, Dell Medical School, University of Texas at Austin, 1501 Red River Street, Austin, TX, 78712, USA.
Rodney O TuckerDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-2041, USA.
Marie BakitasSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA. mbakitas@uab.edu.ORCID http://orcid.org/0000-0002-2913-2053
University of Alabama at Birmingham · USThe University of Texas at Austin · US

Funding

NRSA Training CoreTL1TR003106 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2019 to 2023
$3.7M
ENABLE: CHF-PC (Comprehensive Heartcare For Patients and Caregivers)R01NR013665 · NINR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BAKITAS, MARIE ANNE · 2015 to 2019
$3.6M
An Upstream Palliative Care Intervention for Rural Family CaregiversK99NR015903 · NINR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ODOM, JAMES N. · 2016 to 2017
$189k
NCATS NIH HHS TL1 TR003106NINR NIH HHS 1K99NR015903NINR NIH HHS 3R01NR013665-02S1NINR NIH HHS K99 NR015903NINR NIH HHS R01 NR013665NINR NIH HHS R01NR13665
6 · The paper itself

Abstract

backgroundPalliative care is specialized medical care for people with serious illness that is focused on providing relief from symptoms and stress and improving the quality of life (QOL) for patients and their families. To help the 6.5 million U.S. adults and families affected by heart failure manage the high symptom burden, complex decision-making, and risk of exacerbation and death, the early integration of palliative care is critical and has been recommended by numerous professional organizations. However, few trials have tested early outpatient community-based models of palliative care for patients diagnosed with advanced heart failure and their caregivers. To address this gap, through a series of formative evaluation trials, we translated an oncology early palliative care telehealth intervention for heart failure to create ENABLE CHF-PC (Educate, Nurture, Advise, Before Life Ends, Comprehensive Heartcare for Patients and Caregivers). METHODS/

designThe primary objective of this multisite pragmatic randomized controlled trial is to test the efficacy of ENABLE CHF-PC plus usual heart failure care compared to usual care alone. Community-dwelling persons who are ≥50 years of age with New York Heart Association class III/IV or American Heart Association/American College of Cardiology stage C/D heart failure and their primary caregiver (if present) are being randomized to one of two study arms. The ENABLE CHF-PC intervention group receives usual heart failure care plus an in-person palliative care assessment by a board-certified palliative care provider (caregivers are invited to attend), a series of nurse coach-led, weekly psychoeducational 20 to 60 min phone sessions using a guidebook called Charting Your Course (patients: 6 sessions and caregivers: 4 sessions), and monthly check-in calls. Charting Your Course topical content includes problem-solving, coping, self-care and symptom management, communication, decision-making, advance care planning, and life review (patients only). Primary outcomes include patient QOL and mood (depressive symptoms/anxiety) and caregiver QOL, mood, and burden at 8 and 16 weeks after baseline. Outcomes will be examined using an intention-to-treat approach and mixed effects modeling for repeated measures. DISCUSSION: This trial will determine whether the ENABLE CHF-PC model of concurrent heart failure palliative care is superior to usual heart failure care alone in achieving higher patient and caregiver QOL, improving mood, and lowering burden.

trial registrationClinicalTrials.gov, NCT02505425 . Registered on 22 July 2015.

Indexed as

Health Knowledge, Attitudes, PracticeAdaptation, PsychologicalAdolescentAdultAffectAgedAged, 80 and overCaregiversCost of IllnessDelivery of Health Care, IntegratedFemaleHeart FailureHumansMaleMiddle AgedMulticenter Studies as TopicAccessPalliative carePsychoeducational interventionTelehealth

Identifiers

PMID30081933
PMCPMC6090835
OpenAlexW2885648448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.