ArticleJournal of neuroinflammation2018
Methylprednisolone treatment enhances early recovery following surgical decompression for degenerative cervical myelopathy without compromise to the systemic immune system.
Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Evaluation of postoperative nerve root oedema and analysis of risk factors in unilateral biportal endoscopic discectomy using the DESS sequence: preliminary results.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Posterior Only Reduction and Fixation of The Basilar Invagination and Atlantoaxial Dislocation Secondary to Severe Rheumatoid Arthritis: A Technical Note.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Antibiotic administration decreases microglia and macrophage recruitment in a sex-dependent manner following Degenerative Cervical Myelopathy.Molecular neurobiology · 2025Article
- Conservative and newer drug treatment for degenerative cervical myelopathy.Journal of clinical orthopaedics and trauma · 2025Article
- Ischemia-reperfusion injury after spinal cord decompressive surgery-An in vivo rat model.Animal models and experimental medicine · 2025Article
- Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats.Immunity, inflammation and disease · 2025Article
- Reperfusion injury case following cervical fusion with OPLL: a case report and literature review.Journal of medical case reports · 2024Review
- Pharmacological Treatment of Degenerative Cervical Myelopathy: A Critical Review of Current Evidence.Neurospine · 2024Article
- Degenerative cervical myelopathy: establishing severity thresholds for neuromotor dysfunction in the aging spine using the NIH Toolbox Assessment Scale.GeroScience · 2024Article
- Pharmacological interventions targeting the microcirculation following traumatic spinal cord injury.Neural regeneration research · 2024Review
- Cervical Myelopathy Due to Epidural Hematoma at the Cervicomedullary Junction Associated With Ventriculoperitoneal Shunt Overdrainage: A Case Report.Brain & NeuroRehabilitation · 2023Article
- Postoperative Morbidity and Mortality in Lumbar Spine Surgery Patients With Chronic Kidney Disease and Chronic Steroid Use.International journal of spine surgery · 2023Article
- Post-operative steroids in patients with patients with severe cerebral palsy undergoing posterior spinal fusion.Spine deformity · 2023Article
- Case report: Medulla oblongata and cervical cord reperfusion injury after intracranial vertebral artery angioplasty and stenting.Frontiers in neurology · 2023Article
- Degenerative Cervical Myelopathy induces sex-specific dysbiosis in mice.Frontiers in microbiology · 2023Article
- White Cord Syndrome: A Reperfusion Injury Following Spinal Decompression Surgery.Korean journal of neurotrauma · 2022Article
- Letter to the Editor: Commentary on White Cord Syndrome: A Reperfusion Injury Following Spinal Decompression Surgery (Korean journal of neurotrauma · 2022Article
- Acute Systemic White Blood Cell Changes following Degenerative Cervical Myelopathy (DCM) in a Mouse Model.International journal of molecular sciences · 2022Article
- Cacna2d2 inhibits axonal regeneration following surgical decompression in a rat model of cervical spondylotic myelopathy.BMC neuroscience · 2022Article
- Developing Novel Therapies for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 7]: Opportunities From Restorative Neurobiology.Global spine journal · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDegenerative cervical myelopathy (DCM) is caused by degenerative or congenital changes to the discs and soft tissues of the cervical spine, which leads to chronic compression of the spinal cord. The current treatment for moderate to severe DCM consists of surgical decompression, which, while effective in most cases, can result in neuroinflammation and spinal cord reperfusion injury, leading to perioperative neurological complications and suboptimal neurological recovery. The primary objective of this study was to assess, in a translationally relevant animal model of DCM, the efficacy of perioperative methylprednisolone (MP) in enhancing neurological recovery and to evaluate its effect on the inflammatory response following decompression.
methodsDCM was induced in C57BL/6 mice. Briefly, an aromatic polyether material was implanted underneath the C5-C6 laminae to cause progressive compression of the cervical spinal cord due to focal ossification. Decompressive surgery was undertaken at 12 weeks post initial biomaterial implantation. Animals received one dose of MP (30 mg/kg) or vehicle 30 min before decompression and at 2 weeks after decompression. Acute analysis of secreted cytokines and spinal cord microvasculature was complemented with immunohistochemistry for glial and neuronal cell markers. Locomotor outcomes were measured using the CatWalk system. The composition of circulating white blood cells was analyzed by flow cytometry.
resultsA single dose of MP before decompression significantly sped locomotor recovery (*p < 0.05) and reduced the incidence of perioperative motor complications, without affecting the composition of circulating white blood cells. Histological assessment of the spinal cord showed significant neuronal preservation and a modest reduction in parenchymal inflammation.
conclusionsOur data suggest that MP reduces perioperative neurological complications following decompressive surgery for DCM by protecting neurons from inflammation, without compromising the composition of circulating immune cells. We propose that MP, which is commonly used for neurological disorders including spinal cord injury, be considered as a perioperative adjunct to decompressive surgery to attenuate neurological complications.
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