ArticleACS nano2018
Microfluidics Synthesis of Gene Silencing Cubosomes.
Article in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 98 citations in OpenAlex.
- Design of liquid crystalline nanoparticles: Linking composition to membrane interactions and siRNA delivery.International journal of pharmaceutics: X · 2026Article
- Viral Infection-Inspired Autonomous Detection of Fusion-Competent Viruses for Screening and Environmental Surveillance.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Topological Approach to Measuring the Gaussian Curvature Modulus of Lipid Membranes in Simulation.Physical review letters · 2026Article
- Article
- Microfluidic Flow-Focusing for Size-Controlled Formation of Cubosomes.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Harnessing Microfluidics for the Effective and Precise Synthesis of Advanced Materials.Micromachines · 2025Review
- Premixing enables loading of long RNA in cubic phase lipid nanoparticles.Nature communications · 2025Article
- Fusogenic lipid nanoparticles for rapid delivery of large therapeutic molecules to exosomes.Nature communications · 2025Article
- Review
- Click Lipid Nanoparticles for the Delivery of mRNA to Metabolically Labeled Cancer Cells.Biochemistry · 2025Article
- Advances and prospects of RNA delivery nanoplatforms for cancer therapy.Acta pharmaceutica Sinica. B · 2025Review
- Lipid Membrane Leaflets Unzip upon Hybridization with Polymer-Rich Nanodomains.Macromolecules · 2024Article
- Ionizable Lipid Containing Nanocarriers for Antimicrobial Agent Delivery.Small science · 2024Article
- Mixtures of Intrinsically Disordered Neuronal Protein Tau and Anionic Liposomes Reveal Distinct Anionic Liposome-Tau Complexes Coexisting with Tau Liquid-Liquid Phase Separated Coacervates.bioRxiv : the preprint server for biology · 2024Article
- Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications.Journal of lipids · 2024Review
- Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Microfluidic synthesis of multilayered lipid-polymer hybrid nanoparticles for the formulation of low solubility drugs.Soft matter · 2023Article
- Microfluidic Manufacture of Lipid-Based Nanomedicines.Pharmaceutics · 2022Review
- Microfluidic Nanomaterial Synthesis and In Situ SAXS, WAXS, or SANS Characterization: Manipulation of Size Characteristics and Online Elucidation of Dynamic Structural Transitions.Molecules (Basel, Switzerland) · 2022Review
- Coupling Lipid Nanoparticle Structure and Automated Single-Particle Composition Analysis to Design Phospholipase-Responsive Nanocarriers.Advanced materials (Deerfield Beach, Fla.) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
The success of gene technologies hinges on our ability to engineer superior encapsulation and delivery vectors. Cubosomes are lipid-based nanoparticles where membranes, instead of enveloping into classic liposomes, intertwine into complex arrays of pores well-ordered in a cubic lattice. These complex nanoparticles encapsulate large contents of siRNA compared to a liposomal analogue. Importantly, the membranes that form cubosomes have intrinsic fusogenic properties that promote fast endosomal escape. Despite the great potential, traditional routes of forming cubosomes lead to particle sizes too large to fulfill the state-of-the art requirements of delivery vectors. To overcome this challenge, we utilize a microfluidic nanomanufacturing device to synthesize cubosomes and siRNA-loaded cubosomes, termed cuboplexes. Utilizing cryogenic TEM and small angle X-ray scattering we elucidate the time-resolved mechanisms in which microfluidic devices allow the production of small cubosomes and cuboplexes (75 nm) that outperform commercially available delivery vectors, as well as liposome-based systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.