Evidence map›Paper›PMID 30081533›Full record

ArticleSensors (Basel, Switzerland)2018

Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations.

Pablo Pérez, Gloria Huertas, Alberto Olmo, Andrés Maldonado-Jacobi, Juan A Serrano, María E Martín, Paula Daza, Alberto Yúfera

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pablo PérezInstituto de Microelectrónica de Sevilla, IMSE, CNM (Universidad de Sevilla, CSIC), Av. Américo Vespucio, SN, 41092 Sevilla, Spain. pablopg@imse-cnm.csic.es.
Gloria HuertasInstituto de Microelectrónica de Sevilla, IMSE, CNM (Universidad de Sevilla, CSIC), Av. Américo Vespucio, SN, 41092 Sevilla, Spain. gloria@imse-cnm.csic.es.
Alberto OlmoInstituto de Microelectrónica de Sevilla, IMSE, CNM (Universidad de Sevilla, CSIC), Av. Américo Vespucio, SN, 41092 Sevilla, Spain. aolmo@dte.us.es.ORCID 0000-0001-6388-4462
Andrés Maldonado-JacobiInstituto de Microelectrónica de Sevilla, IMSE, CNM (Universidad de Sevilla, CSIC), Av. Américo Vespucio, SN, 41092 Sevilla, Spain. maldonado@imse-cnm.csic.es.
Juan A SerranoInstituto de Microelectrónica de Sevilla, IMSE, CNM (Universidad de Sevilla, CSIC), Av. Américo Vespucio, SN, 41092 Sevilla, Spain. serrano@imse-cnm.csic.es.
María E MartínDepartamento de Biología Celular, Facultad de Biología, Universidad de Sevilla, Av. Reina Mercedes, SN, 41012 Sevilla, Spain. mariamartin@us.es.
Paula DazaDepartamento de Biología Celular, Facultad de Biología, Universidad de Sevilla, Av. Reina Mercedes, SN, 41012 Sevilla, Spain. pdaza@us.es.
Alberto YúferaInstituto de Microelectrónica de Sevilla, IMSE, CNM (Universidad de Sevilla, CSIC), Av. Américo Vespucio, SN, 41092 Sevilla, Spain. yufera@imse-cnm.csic.es.ORCID 0000-0002-1814-6089

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A smart sensor system for cell culture real-time supervision is proposed, allowing for a significant reduction in human effort applied to this type of assay. The approach converts the cell culture under test into a suitable "biological" oscillator. The system enables the remote acquisition and management of the "biological" oscillation signals through a secure web interface. The indirectly observed biological properties are cell growth and cell number, which are straightforwardly related to the measured bio-oscillation signal parameters, i.e., frequency and amplitude. The sensor extracts the information without complex circuitry for acquisition and measurement, taking advantage of the microcontroller features. A discrete prototype for sensing and remote monitoring is presented along with the experimental results obtained from the performed measurements, achieving the expected performance and outcomes.

Indexed as

PeriodicityCell Culture TechniquesCell EnlargementCell ProliferationTelemetrybioimpedancecell cultureOBTreal-time monitoringsmart sensing

Identifiers

PMID30081533
PMCPMC6112038

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.