Evidence map›Paper›PMID 30081479›Full record

ArticleToxics2018

Health Impacts and Biomarkers of Prenatal Exposure to Methylmercury: Lessons from Minamata, Japan.

Mineshi Sakamoto, Nozomi Tatsuta, Kimiko Izumo, Phuong Thanh Phan, Loi Duc Vu, Megumi Yamamoto, Masaaki Nakamura, Kunihiko Nakai, Katsuyuki Murata

Open access · goldAbstract read
In one paragraph

Article in Toxics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 80 citations in OpenAlex.

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  13. Ecological perspectives on water, food, and health security linkages: the Minamata case in Japan.Environmental science and pollution research international · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Mineshi SakamotoNational Institute for Minamata Disease, Minamata, Kumamoto 867-0008, Japan. sakamoto@nimd.go.jp.
Nozomi TatsutaDevelopment and Environmental Medicine, Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan. nozomi@med.tohoku.ac.jp.
Kimiko IzumoNational Institute for Minamata Disease, Minamata, Kumamoto 867-0008, Japan. izumo@nimd.go.jp.
Phuong Thanh PhanFaculty of Chemistry, Thai Nguyen University of Sciences, Thai Nguyen 250000, Vietnam. phuongqtdhkh@gmail.com.
Loi Duc VuInstitute of Chemistry, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam. ducloi@ich.vast.vn.
Megumi YamamotoNational Institute for Minamata Disease, Minamata, Kumamoto 867-0008, Japan. yamamoto@nimd.go.jp.
Masaaki NakamuraNational Institute for Minamata Disease, Minamata, Kumamoto 867-0008, Japan. nakamura@nimd.go.jp.
Kunihiko NakaiDevelopment and Environmental Medicine, Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan. winestem@med.akita-u.ac.jp.
Katsuyuki MurataDepartment of Environmental Health Sciences, Akita University School of Medicine, Akita 010-8543, Japan. satoc@med.tohoku.ac.jp.
National Institute for Minamata Disease · JPTohoku University · JPAkita University · JPThai Nguyen University · VNVietnam Academy of Science and Technology · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main chemical forms of mercury are elemental mercury, inorganic divalent mercury, and methylmercury, which are metabolized in different ways and have differing toxic effects in humans. Among the various chemical forms of mercury, methylmercury is known to be particularly neurotoxic, and was identified as the cause of Minamata disease. It bioaccumulates in fish and shellfish via aquatic food webs, and fish and sea mammals at high trophic levels exhibit high mercury concentrations. Most human methylmercury exposure occurs through seafood consumption. Methylmercury easily penetrates the blood-brain barrier and so can affect the nervous system. Fetuses are known to be at particularly high risk of methylmercury exposure. In this review, we summarize the health effects and exposure assessment of methylmercury as follows: (1) methylmercury toxicity, (2) history and background of Minamata disease, (3) methylmercury pollution in the Minamata area according to analyses of preserved umbilical cords, (4) changes in the sex ratio in Minamata area, (5) neuropathology in fetuses, (6) kinetics of methylmercury in fetuses, (7) exposure assessment in fetuses.

Indexed as

exposure assessmentfetuskineticsmethylmercurytoxicity

Identifiers

PMID30081479
PMCPMC6161157
OpenAlexW2887269283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.