Evidence map›Paper›PMID 30081290›Full record

ArticlePsychiatry research. Neuroimaging2018

Estimating glutamate and Glx from GABA-optimized MEGA-PRESS: Off-resonance but not difference spectra values correspond to PRESS values.

Richard J Maddock, Michael D Caton, J Daniel Ragland

Abstract read
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In one paragraph

Article in Psychiatry research. Neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  14. Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  15. Article
  16. Article
  17. Higher striatal glutamate in male youth with internet gaming disorder.European archives of psychiatry and clinical neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard J MaddockImaging Research Center, University of California Davis Medical Center, 4701 X, Street, Sacramento, CA 95817, USA; Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, 2230 Stockton Blvd, Sacramento, CA 95817, USA. Electronic address: rjmaddock@ucdavis.edu.
Michael D CatonDepartment of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, 2230 Stockton Blvd, Sacramento, CA 95817, USA. Electronic address: mdcaton@ucdavis.edu.
J Daniel RaglandImaging Research Center, University of California Davis Medical Center, 4701 X, Street, Sacramento, CA 95817, USA; Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, 2230 Stockton Blvd, Sacramento, CA 95817, USA. Electronic address: jdragland@ucdavis.edu.

Funding

UC Davis Conte Center: Neuroimmune Mechanisms of Psychiatric DisordersP50MH106438 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HANKS, TIMOTHY D. · 2015 to 2025
$26.1M
Neural Mechanisms of Memory Dysfunction in SchizophreniaR01MH105411 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAGLAND, JOHN D, RANGANATH, CHARAN · 2015 to 2018
$1.9M
NIMH NIH HHS P50 MH106438NIMH NIH HHS R01 MH105411
6 · The paper itself

Abstract

Proton magnetic resonance spectroscopy measurements of glutamate and GABA are important in neuropsychiatric research. Some study designs require simultaneous measurement of both metabolites. GABA measurement requires specialized pulse sequences, the most common approach being J-difference spectral editing with MEGA-PRESS. This method enables two different strategies for concurrently measuring glutamate - from either off-resonance or difference spectra. However, it is uncertain how either strategy compares to conventional glutamate measurements. Here we compared these approaches in 49 subjects (28 healthy volunteers and 21 first-episode psychosis patients), in whom both PRESS (TE 80) and MEGA-PRESS (TE 68) spectra were obtained from dorsolateral prefrontal cortex. Glutamate and glx estimates from MEGA-PRESS difference and off-resonance spectra were compared to glutamate and glx estimates from PRESS spectra using correlational analyses. In healthy volunteers, correlations between PRESS and MEGA-PRESS off-resonance values were r ≥ 0.88 and were significantly higher than correlations between PRESS and MEGA-PRESS difference spectrum values (r ≤ 0.36). Patients showed a similar pattern. Lower correlations with difference spectrum values may reflect a disproportionate impact of field instabilities on co-edited glutamate signals. The results suggest that MEGA-PRESS off-resonance spectra can substitute for separately-acquired PRESS spectra in studies requiring simultaneous glutamate and GABA measurements.

Indexed as

AdolescentAdultFemalegamma-Aminobutyric AcidGlutamic AcidHealthy VolunteersHumansMagnetic Resonance SpectroscopyMalePrefrontal CortexProton Magnetic Resonance SpectroscopyYoung Adultgamma-Aminobutyric AcidGlutamic AcidBrainGABAGlutamateMeasurementMetabolitesMRSSimultaneous

Identifiers

PMID30081290
PMCPMC6105414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.