Trial reportAmerican journal of ophthalmology2018
The Relationship Between Optic Disc Volume, Area, and Frisén Score in Patients With Idiopathic Intracranial Hypertension.
Trial report in American journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Exploring the utility of retinal optical coherence tomography as a biomarker for idiopathic intracranial hypertension: a systematic review.Journal of neurology · 2024Pooled it
- Automated Retinal Vascular Analysis Reveals Response to Acetazolamide in Idiopathic Intracranial Hypertension.Translational vision science & technology · 2025Trial
- Retinal vessel diameter changes after 6 months of treatment in the Idiopathic Intracranial Hypertension Treatment Trial.The British journal of ophthalmology · 2020Trial
- Diagnosis of High Intracranial Pressure by Non-Optic Nerve Retinal Image Features.Translational vision science & technology · 2026Article
- Visual prognosis in idiopathic intracranial hypertension: observations from a retrospective cohort in Germany.Frontiers in neurology · 2025Article
- Visualization of Optic Nerve Structural Patterns in Papilledema Using Deep Learning Variational Autoencoders.Translational vision science & technology · 2024Article
- Classifying and quantifying changes in papilloedema using machine learning.BMJ neurology open · 2024Article
- Neurofilament light chain marks severity of papilledema in idiopathic intracranial hypertension.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Neuro-ophthalmological evaluation including optical coherence tomography surrounding venous sinus stenting in idiopathic intracranial hypertension with papilledema: a case series.Neurosurgical review · 2022Article
- Optical coherence tomography use in idiopathic intracranial hypertension.Annals of eye science · 2020Article
- An Update on Imaging in Idiopathic Intracranial Hypertension.Frontiers in neurology · 2020Review
- Update on the Diagnosis and Treatment of Idiopathic Intracranial Hypertension.Seminars in neurology · 2019Review
- Clinical and demographic differences between idiopathic intracranial hypertension patients with mild and severe papilledema.Taiwan journal of ophthalmologyArticle
- Assessment of optic nerve sheath enlargement and Frisen classification in idiopathic intracranial hypertension: Implications for estimating intracranial pressure and grading chronic papilledema.Taiwan journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo compare measurements of papilledema using fundus photography, optical coherence tomography (OCT), and Frisén score in patients with idiopathic intracranial hypertension (IIH).
designRetrospective, noncomparative analysis of randomized controlled trial data.
methodsThe Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) evaluated weight management and treatment with acetazolamide compared with placebo in patients with IIH and mild visual loss. Among the 126 subjects in the IIHTT OCT substudy, fundus photographs and OCT scans of the optic disc were taken at baseline and at 6 and 12 months after enrollment. Trained readers scored each eye using a modified Frisén scale and measured the area of disc elevation. OCT scans assessed optic nerve head (ONH) volume. Correlations between volume and area were computed for both study and nonstudy eyes.
resultsDisc area and ONH volume were positively correlated at baseline (R
conclusionFrisén score fails to reflect the photographic area and OCT volume of papilledema after treatment with acetazolamide. Clinicians should use caution when using the Frisén scale to monitor the effect of treatment on papilledema over time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.