ArticleAlcoholism, clinical and experimental research2018
Sex Differences in Motivation to Self-Administer Alcohol After 2 Weeks of Abstinence in Young-Adult Heavy Drinkers.
Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Using naltrexone to validate a human laboratory test system to screen new medications for alcoholism (TESMA)- a randomized clinical trial.Translational psychiatry · 2023Trial
- Effects of short-term abstinence on alcohol elimination rate: Sex differences and method comparisons using the intravenous alcohol clamp.Alcohol (Fayetteville, N.Y.) · 2026Article
- Individualized assignment to short-term alcohol abstinence: A proof-of-concept human laboratory study using psychopathology dimensions.Drug and alcohol dependence reports · 2026Article
- Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice.Brain sciences · 2026Article
- Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior.Neurobiology of stress · 2024Article
- Sex chromosome and gonadal hormone contributions to binge-like and aversion-resistant ethanol drinking behaviors in Four Core Genotypes mice.Frontiers in psychiatry · 2023Article
- Gonadal hormones and sex chromosome complement differentially contribute to ethanol intake, preference, and relapse-like behaviour in four core genotypes mice.Addiction biology · 2022Article
- Binge and high-intensity drinking-Associations with intravenous alcohol self-administration and underlying risk factors.Addiction biology · 2022Article
- Translating preclinical models of alcohol seeking and consumption into the human laboratory using intravenous alcohol self-administration paradigms.Addiction biology · 2021Article
- Exploring regulation and function of dopamine D3 receptors in alcohol use disorder. A PET [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Translational opportunities in animal and human models to study alcohol use disorder.Translational psychiatry · 2021Review
- Association between Alcohol Drinking Status and Depressive Symptoms in Korean Adults.Chonnam medical journal · 2021Article
- To Infuse or Ingest in Human Laboratory Alcohol Research.Alcoholism, clinical and experimental research · 2020Review
- Sex Differences in the Neurobiology of Alcohol Use Disorder.Alcohol research : current reviews · 2020Review
- Review: Sex-Based Differences in Treatment Outcomes for Persons With Opioid Use Disorder.The American journal on addictions · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundStudies in animal models document that forced abstinence from usual consumption of alcohol changes subsequent seeking and consumption, with increases or decreases depending on the species, duration of abstinence, number of deprivations, and sex. Human laboratory-based alcohol deprivation studies are rare.
methodsWe conducted a 2-session, within-participant, randomized-order comparison of intravenous, progressive ratio, alcohol self-administration during 2.5 hours of progressive work for alcohol and/or vehicle; once while the participants pursued their usual drinking habits and once after 2 weeks of closely monitored, voluntary outpatient abstinence from alcohol. The schedule of work for rewards and the incremental increases in breath alcohol concentration following completion of an alcohol work-set were identical across participants. Fifty young-adult (27 men), heavy-drinking participants completed both sessions. Our primary hypothesis was that motivation to work for alcohol after 2 weeks of abstinence would be greater in participants with a weekly binge pattern of drinking, compared to those who regularly drink heavily, and we intended to explore associations with biological family history of alcoholism and sex.
resultsWe detected no change in work for alcohol associated with recent drinking history. However, females, on average, increased their work for alcohol upon resumption after 2 weeks of abstinence (mean ± SEM = +16.3 ± 9.6%), while males decreased that work (-24.8 ± 13.8%). The sex difference was substantial and significant (p < 0.03), with a medium effect size (Cohen's d = 0.63).
conclusionsWe believe a more comprehensive study of mechanisms underlying the sex differences in the human postabstinence response is warranted.
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