Evidence map›Paper›PMID 30080138›Full record

ArticleeLife2018

Exploiting natural regulation.

Catherine Proenza

Open access · goldAbstract readComment
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  3. Cardiac Pacemaker Activity and Aging.Annual review of physiology · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Catherine ProenzaDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID 0000-0003-4324-6206
University of Colorado Anschutz Medical Campus · US

Funding

Regulation of excitability in sinoatrial myocytesR01HL088427 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI PROENZA, CATHERINE · 2008 to 2024
$5.8M
NHLBI NIH HHS R01 HL088427
6 · The paper itself

Abstract

Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs.

Indexed as

Cyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsCyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated Channelsallosteric regulationcAMPcardiac pacemakerHCN channelsmolecular biophysicsmousestructural biologyTRIP8b

Identifiers

PMID30080138
PMCPMC6078491
OpenAlexW2885374944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.