ArticleAmerican journal of respiratory and critical care medicine2019
Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort.
Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urban Environment and Childhood Asthma (URECA)
Correlation of Physical Activity and Respiratory Health in COPD Patient
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Pooled it
- The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- TheBMJ open respiratory research · 2026Observational
- Joint modelling of wheeze and lung function from childhood to early adulthood: four population-based birth cohorts.EClinicalMedicine · 2026Article
- Echoes of smoke: unwinding multigenerational asthma risk through longitudinal cohorts.ERJ open research · 2026Article
- Association Between Prenatal Antibiotic Exposure and Infant Wheeze Outcomes.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- The Microbiome in Asthma Heterogeneity: The Role of Multi-Omic Investigations.Immunological reviews · 2025Review
- Integrating Exposures and Multi-Omics in the Boston Birth Cohort to Elucidate Immune Development across the Life Course: Rationale and Study Design.Precision nutrition · 2025Article
- Clinical and molecular analysis of longitudinal rhinitis phenotypes in an urban birth cohort.The Journal of allergy and clinical immunology · 2025Article
- The Impact of the Indoor Environment on Childhood Asthma.Current allergy and asthma reports · 2025Review
- Adult Outcomes of Childhood Wheezing Phenotypes Are Associated with Early-Life Factors.Journal of personalized medicine · 2024Article
- Machine learning-derived phenotypic trajectories of asthma and allergy in children and adolescents: protocol for a systematic review.BMJ open · 2024Article
- Viral and non-viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Early-life nasal microbiota dynamics relate to longitudinal respiratory phenotypes in urban children.The Journal of allergy and clinical immunology · 2024Article
- Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.The Journal of allergy and clinical immunology · 2024Article
- Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.Nature communications · 2024Article
- Artificial intelligence and wheezing in children: where are we now?Frontiers in medicine · 2024Review
- Respiratory disease patterns in rural Western Uganda, 2019-2022.Frontiers in pediatrics · 2024Article
- Unanswered questions on the use of biologics in pediatric asthma.The World Allergy Organization journal · 2023Review
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 1 country.
Funding
Abstract
rationaleCharacterization of patterns of wheezing and allergic sensitization in early life may allow for identification of specific environmental exposures impacting asthma development.
objectivesTo define respiratory phenotypes in inner-city children and their associations with early-life environmental exposures.
methodsData were collected prospectively from 442 children in the URECA (Urban Environment and Childhood Asthma) birth cohort through age 7 years, reflecting symptoms (wheezing), aeroallergen sensitization, pulmonary function, and body mass index. Latent class mixed models identified trajectories of wheezing, allergic sensitization, and pulmonary function. Cluster analysis defined nonoverlapping groups (termed phenotypes). Potential associations between phenotypes and early-life environmental exposures were examined. MEASUREMENTS AND MAIN
resultsFive phenotypes were identified and mainly differentiated by patterns of wheezing and allergic sensitization (low wheeze/low atopy; low wheeze/high atopy; transient wheeze/low atopy; high wheeze/low atopy; high wheeze/high atopy). Asthma was most often present in the high-wheeze phenotypes, with greatest respiratory morbidity among children with frequent wheezing and allergic sensitization. These phenotypes differentially related to early-life exposures, including maternal stress and depression, antenatal environmental tobacco smoke, house dust microbiome, and allergen content (all P < 0.05). Prenatal smoke exposure, maternal stress, and depression were highest in the high-wheeze/low-atopy phenotype. The high-wheeze/high-atopy phenotype was associated with low household microbial richness and diversity. Early-life aeroallergen exposure was low in high-wheeze phenotypes.
conclusionsPatterns of wheezing, allergic sensitization, and lung function identified five respiratory phenotypes among inner-city children. Early-life environmental exposure to stress, depression, tobacco smoke, and indoor allergens and microbes differentially associate with specific phenotypes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.