Evidence map›Paper›PMID 30079756›Full record

Trial reportBiological research for nursing2019

A Large Randomized Trial: Effects of Mindfulness-Based Stress Reduction (MBSR) for Breast Cancer (BC) Survivors on Salivary Cortisol and IL-6.

Cecile A Lengacher, Richard R Reich, Carly L Paterson, Melissa Shelton, Steve Shivers, Sophia Ramesar, Michelle L Pleasant, Pinky Budhrani-Shani, Maureen Groer, Janice Post-White and 6 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biological research for nursing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06090747 (Efecto de Una intervención Multidisciplinaria de Estilo de Vida Sobre el Exposoma de Pacientes premenopáusicas Con cáncer de Mama Estadios I-III.), which is not on this map. Cited by 59 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 6 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06090747 narecruitingnot on this mapstarted 2023, after this paper: background citation

Efecto de Una intervención Multidisciplinaria de Estilo de Vida Sobre el Exposoma de Pacientes premenopáusicas Con cáncer de Mama Estadios I-III.

TypeinterventionalSponsorInstituto Nacional de Cancerologia de MexicoRan2023 to 2028Enrolled146ConditionsBreast NeoplasmArmsHybrid lifestyle educational multidisciplinary intervention., Hybrid lifestyle personalized multidisciplinary intervention.
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 117 citations in OpenAlex.

  1. Pooled it
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  5. Psychological interventions for women with non-metastatic breast cancer.The Cochrane database of systematic reviews · 2023
    Pooled it
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  11. Article
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  13. [Mechanisms and intervention strategies by which neuropsychological stress promotes central nervous system tumor recurrence through bloodZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
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  15. Beyond tumor biology: nursing interventions for psychological and immune health in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Cecile A Lengacher1 College of Nursing, University of South Florida, Tampa, FL, USA.
Richard R Reich2 H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Carly L Paterson3 Patient-Centered Outcomes Research Institute, Washington, DC, USA.
Melissa Shelton1 College of Nursing, University of South Florida, Tampa, FL, USA.
Steve Shivers4 Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Sophia Ramesar1 College of Nursing, University of South Florida, Tampa, FL, USA.
Michelle L Pleasant5 Health Services Advisory Group, Tampa, FL, USA.
Pinky Budhrani-Shani6 College of Nursing, Texas Woman's University, Houston, TX, USA.
Maureen Groer1 College of Nursing, University of South Florida, Tampa, FL, USA.
Janice Post-White7 University of Minnesota Twin Cities, Minneapolis, MN, USA.ORCID 0000-0001-5472-5670
Versie Johnson-Mallard8 College of Nursing, University of Florida, Gainesville, FL, USA.
Bradley Kane1 College of Nursing, University of South Florida, Tampa, FL, USA.
Lakeshia Cousin1 College of Nursing, University of South Florida, Tampa, FL, USA.
Manolete S Moscoso1 College of Nursing, University of South Florida, Tampa, FL, USA.
Tiffany A Romershausen1 College of Nursing, University of South Florida, Tampa, FL, USA.
Jong Y Park2 H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
University of South Florida · USMoffitt Cancer Center · USPatient-Centered Outcomes Research Institute · USTexas Woman's University · USUniversity of Florida · USUniversity of Minnesota · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
MBSR Symptom Cluster Trial for Breast Cancer SurvivorsR01CA131080 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI LENGACHER, CECILE A · 2009 to 2013
$2.7M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA131080
6 · The paper itself

Abstract

Breast cancer survivors (BCS) often experience psychological and physiological symptoms after cancer treatment. Mindfulness-based stress reduction (MBSR), a complementary and alternative therapy, has reduced subjective measures of stress, anxiety, and fatigue among BCS. Little is known, however, about how MBSR affects objective markers of stress, specifically the stress hormone cortisol and the pro-inflammatory cytokine interleukin-6 (IL-6). In the present study, BCS ( N = 322) were randomly assigned to a 6-week MBSR program for BC or usual-care control. Measurements of cortisol, IL-6, symptoms, and quality of life were obtained at orientation and 6 weeks. Cortisol and IL-6 were also measured prior to and after the MBSR(BC) class Weeks 1 and 6. The mean age of participants was 56.6 years and 69.4% were White non-Hispanic. Most had Stage I (33.8%) or II (35.7%) BC, and 35.7% had received chemotherapy and radiation. Cortisol levels were reduced immediately following MBSR(BC) class compared to before the class Weeks 1 and 6 (Wilcoxon-signed rank test; p < .01, d = .52-.56). IL-6 was significantly reduced from pre- to postclass at Week 6 (Wilcoxon-signed rank test; p < .01, d = .21). No differences were observed between the MBSR(BC) and control groups from baseline to Week 6 using linear mixed models. Significant relationships with small effect sizes were observed between IL-6 and both symptoms and quality of life in both groups. Results support the use of MBSR(BC) to reduce salivary cortisol and IL-6 levels in the short term in BCS.

Indexed as

MindfulnessAdultAgedBiomarkersBreast NeoplasmsCancer SurvivorsFemaleFloridaHumansHydrocortisoneInterleukin-6Middle AgedSalivaStress, PsychologicalBiomarkersHydrocortisoneInterleukin-6breast cancercytokinemindfulness-based stress reductionstress hormone

Identifiers

PMID30079756
PMCPMC6700883
OpenAlexW2886649495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.