Evidence map›Paper›PMID 30079436›Full record

ArticleJournal of abnormal child psychology2019

The Course of Neurocognitive Functioning and Prediction of Behavioral Outcome of ADHD Affected and Unaffected Siblings.

M van Lieshout, M Luman, L J S Schweren, J W R Twisk, S V Faraone, D J Heslenfeld, C A Hartman, P J Hoekstra, B Franke, J K Buitelaar and 2 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of abnormal child psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  4. An examination of the relationships between attention/deficit hyperactivity disorder symptoms and functional connectivity over time.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M van LieshoutClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081, BT, Amsterdam, The Netherlands. m.van.lieshout@vu.nl.ORCID 0000-0002-4803-8409
M LumanClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081, BT, Amsterdam, The Netherlands.
L J S SchwerenDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
J W R TwiskDepartment of Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
S V FaraoneDepartments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.
D J HeslenfeldClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081, BT, Amsterdam, The Netherlands.
C A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
P J HoekstraDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
B FrankeDepartment of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
J K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
N N J RommelseDepartment of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
J OosterlaanClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081, BT, Amsterdam, The Netherlands.

Funding

International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
NIMH NIH HHS R01 MH062873
6 · The paper itself

Abstract

Longitudinal studies on the course of neurocognitive functioning of children with ADHD and their unaffected siblings are scarce. Also, it is unclear to what extent that course is related to ADHD outcomes. A carefully phenotyped large sample of 838 Caucasian participants (ADHD-combined type: n = 339, unaffected siblings: n = 271, controls: n = 228; mean age at baseline = 11.4 years, mean age at follow-up = 17.3 years, SD = 3.2) was used to investigate differences in the course of neurocognitive functioning of ADHD affected and unaffected siblings versus controls, and to investigate the relationship between neurocognitive change and ADHD outcomes. At baseline, an aggregated measure of overall neurocognitive functioning and eight neurocognitive measures of working memory, timing (speed/variability), motor control, and intelligence were investigated. Outcomes at follow-up were dimensional measures of ADHD symptom severity and the Kiddie-Global Assessment Scale (K-GAS) for overall functioning. At follow up, affected and unaffected siblings trended to, or fully caught up with performance levels of controls on four (44.4%) and five (55.6%) of the nine dependent variables, respectively. In contrast, performance in remaining key neurocognitive measures (i.e. verbal working memory, variability in responding) remained impaired at follow-up. Change in neurocognitive functioning was not related to ADHD outcomes. Our results question the etiological link between neurocognitive deficits and ADHD outcomes in adolescents and young adults.

Indexed as

Outcome Assessment, Health CareSiblingsAdolescentAttention Deficit Disorder with HyperactivityChildChild, PreschoolCognitive DysfunctionFemaleFollow-Up StudiesHumansMaleYoung AdultADHDCourseNeurocognitive functioningOverall functioningSymptom severity

Identifiers

PMID30079436
PMCPMC6397140

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.