Evidence map›Paper›PMID 30079375›Full record

ArticleeNeuro

ΔFosB Decreases Excitability of Dorsal Hippocampal CA1 Neurons.

Andrew L Eagle, Elizabeth S Williams, Joseph A Beatty, Charles L Cox, Alfred J Robison

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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  6. Minocycline Abrogates Individual Differences in Nerve Injury-Evoked Affective Disturbances in Male Rats and Prevents Associated Supraspinal Neuroinflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
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  13. Self-assembly of the bZIP transcription factor ΔFosB.Current research in structural biology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrew L EagleDepartment of Physiology and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824.ORCID 0000-0002-7879-5996
Elizabeth S WilliamsDepartment of Physiology and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824.
Joseph A BeattyDepartment of Physiology and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824.
Charles L CoxDepartment of Physiology and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824.
Alfred J RobisonDepartment of Physiology and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824.
Michigan State University · US

Funding

Projection-specific gene expression in resilience to chronic stressR01MH111604 · NIMH · MICHIGAN STATE UNIVERSITY · PI Michelle Suzanne Mazei-Robison, ALFRED J ROBISON · 2016 to 2026
$4.9M
Synaptic Phenotype, Development, and Plasticity in the Fragile X MouseR01MH085324 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI COX, CHARLES LEROY · 2010 to 2015
$2.1M
NIMH NIH HHS R01 MH085324NIMH NIH HHS R01 MH111604
6 · The paper itself

Abstract

Both the function of hippocampal neurons and hippocampus-dependent behaviors are dependent on changes in gene expression, but the specific mechanisms that regulate gene expression in hippocampus are not yet fully understood. The stable, activity-dependent transcription factor ΔFosB plays a role in various forms of hippocampal-dependent learning and in the structural plasticity of synapses onto CA1 neurons. The authors examined the consequences of viral-mediated overexpression or inhibition of ΔFosB on the function of adult mouse hippocampal CA1 neurons using

Indexed as

AnimalsCA1 Region, HippocampalGene ExpressionLearningMaleMembrane PotentialsMiceMice, Inbred C57BLPatch-Clamp TechniquesProto-Oncogene Proteins c-fosPyramidal CellsFosb protein, mouseProto-Oncogene Proteins c-fosCA1excitabilityhippocampustranscription factorΔFosB

Identifiers

PMID30079375
PMCPMC6073980
OpenAlexW2883259893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.