ArticleBioMed research international2018
High Ghrelin Level Predicts the Curve Progression of Adolescent Idiopathic Scoliosis Girls.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Pooled it
- Disordered leptin and ghrelin bioactivity in adolescent idiopathic scoliosis (AIS): a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Current insights into circulating biomarkers and their potential for predicting adolescent idiopathic scoliosis progression.Frontiers in cell and developmental biology · 2026Review
- Epidemiological survey of scoliosis screening in schools among 51,025 adolescents in Gannan Tibetan autonomous prefecture, Gansu Province, China.Frontiers in public health · 2026Article
- Behavioral effects of academic pressure on the risk of adolescent idiopathic scoliosis: a case-control study.Scientific reports · 2025Article
- Genetics and pathogenesis of scoliosis.North American Spine Society journal · 2024Article
- Scoliosis school screening of 139,922 multi-ethnic children in Dali, southwestern China: A large epidemiological study.iScience · 2023Article
- Metabolic Imbalances and Bone Remodeling Agents in Adolescent Idiopathic Scoliosis: A Study in Postmenarcheal Girls.International journal of molecular sciences · 2023Article
- Circulatory Adipokines and Incretins in Adolescent Idiopathic Scoliosis: A Pilot Study.Children (Basel, Switzerland) · 2022Article
- Predictive value of single-nucleotide polymorphisms in curve progression of adolescent idiopathic scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Review
- Is ghrelin a biomarker of early-onset scoliosis in children with Prader-Willi syndrome?Orphanet journal of rare diseases · 2021Article
- Ghrelin uses the GHS-R1a/Gi/cAMP pathway and induces differentiation only in mature osteoblasts. This ghrelin pathway is impaired in AIS patients.Biochemistry and biophysics reports · 2020Article
- Article
- Skeletal growth velocity of adolescent idiopathic scoliosis: abnormal in spine but normal in lower limbs.Annals of translational medicine · 2020Article
- Dysregulated Bone Metabolism Is Related to High Expression of miR-151a-3p in Severe Adolescent Idiopathic Scoliosis.BioMed research international · 2020Article
- Association of Circulating YKL-40 Levels and CHI3L1 Variants with the Risk of Spinal Deformity Progression in Adolescent Idiopathic Scoliosis.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdolescent idiopathic scoliosis (AIS) is common deformity with unknown cause. Previous studies have suggested the abnormal serum leptin and ghrelin level in AIS girls. The aim of present study was to evaluate whether the serum leptin and ghrelin level could serve as risk factor in predicting the curve progression in AIS girls. The associations between them and the physical characteristics were also investigated. MATERIALS AND
methodsCirculating leptin and ghrelin levels from 105 AIS girls and 40 age-matched non-AIS girls were examined by enzyme-linked immunosorbent assay. The correlations between ghrelin and leptin levels and growth-related parameters (age, weight, corrected height, corrected BMI, main Cobb angle, and Risser sign) were analyzed in AIS group. Multivariate logistic regression was used to investigate factors predicting curve progression in AIS girls.
resultsA significantly lower leptin level (6.55 ± 2.88 vs. 8.01 ± 3.12 ng/ml,
conclusionsHigh ghrelin level may serve as a new quantitative indicator for predicting curve progression in AIS girls.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.