ArticleCilia2018
Evidence of primary cilia in the developing rat heart.
Article in Cilia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Pathological Structural Alterations of Serous Cell Cilia in the Parietal Pericardium of Patients With Heart Failure Induced by Dilated Cardiomyopathy.Reviews in cardiovascular medicine · 2026Article
- Broadening horizons: new links between cilia and heart development and disease.Frontiers in cardiovascular medicine · 2026Review
- Cardiac Localized Polycystin-2 in the Natriuretic Peptide Signaling Pathway and Hypertension.Journal of the American Society of Nephrology : JASN · 2025Article
- The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes.Journal of translational medicine · 2024Article
- Three-dimensional architecture of granulosa cell derived from oocyte cumulus complex, revealed by FIB-SEM.Journal of ovarian research · 2023Article
- Cardiovascular Manifestations and Management in ADPKD.Kidney international reports · 2023Review
- Review
- Association of Nephronophthisis 4 genetic variation with cardiorenal syndrome and cardiovascular events in Japanese general population: the Yamagata (Takahata) study.Heart and vessels · 2022Article
- Review
- Tubulin Post-translational Modifications: Potential Therapeutic Approaches to Heart Failure.Frontiers in cell and developmental biology · 2022Review
- Congenital Heart Disease in Adults with Autosomal Dominant Polycystic Kidney Disease.American journal of nephrology · 2022Article
- Article
- Developmental and regenerative paradigms of cilia regulated hedgehog signaling.Seminars in cell & developmental biology · 2021Review
- Primary Cilia and Atherosclerosis.Frontiers in physiology · 2021Review
- Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy.PloS one · 2021Article
- Low fluid shear stress promoted ciliogenesis via Dvl2 in hUVECs.Histochemistry and cell biology · 2020Article
- Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve.American journal of physiology. Heart and circulatory physiology · 2020Article
- Polycystins, ADPKD, and Cardiovascular Disease.Kidney international reports · 2020Review
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA transient increase in cytosolic Ca
methodsImmunohistochemical techniques were used to identify primary cilia-specific proteins in isolated myocytes from adult rat hearts, and in tissue sections from embryonic, neonatal, young, and adult rat hearts. Either mouse anti-acetylated α-tubulin or rabbit polyclonal ARL13B antibodies were used, counterstained with Hoechst dye. Selected sections were also labelled with markers for other cell types found in the heart and for myocyte F-actin.
resultsNo evidence of primary cilia was found in either tissue sections or isolated myocytes from adult rat ventricles. However, primary cilia were present in tissue sections from embryonic, neonatal (P2) and young (P21 and P28) rat hearts.
conclusionThe lack of primary cilia in adult rat hearts rules out their contribution to myocyte Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.