ArticleChemical science2018
An integrated mass spectrometry platform enables picomole-scale real-time electrosynthetic reaction screening and discovery.
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
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- Paired electrolysis enables para-C-H amination of phenols with nitroarenes and mechanistic visualization via multifunctional electrochemical mass spectrometry.Nature communications · 2026Article
- Capture and identification of the electrogenerated picosecond intermediates by mass spectrometry.Fundamental research · 2026Article
- Microdroplet Stabilization Enabled Direct Mass Spectrometric Identification of Electrogenerated Transient Carbocation Intermediates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Rapid and sensitive detection of polycyclic aromatic hydrocarbons using electrochemically assisted derivatization mass spectrometry.Analytical and bioanalytical chemistry · 2025Article
- Paired Pulsed Decarboxylative Hydroxylation Designed by Online Electrochemistry-Mass Spectrometry.Journal of the American Chemical Society · 2025Article
- Absolute Quantitation of Phosphopeptides and Glycopeptides Using Coulometric Mass Spectrometry.ACS measurement science au · 2025Article
- Screening and dissecting electroorganic synthesis by mass spectrometry decoupling of electrode and homogeneous processes.Nature communications · 2025Article
- Absolute Quantitation of Peptides and Proteins by Coulometric Mass Spectrometry After Derivatization.International journal of mass spectrometry · 2024Article
- Dual Metal Electrolysis in Theta Capillary for Lipid Analysis.International journal of mass spectrometry · 2023Article
- One-Step Regio- and Stereoselective Electrochemical Synthesis of Orexin Receptor Antagonist Oxidative Metabolites.The Journal of organic chemistry · 2022Article
- Simultaneous and Spontaneous Oxidation and Reduction in Microdroplets by the Water Radical Cation/Anion Pair.Angewandte Chemie (International ed. in English) · 2022Article
- Electrocatalytic redox neutral [3 + 2] annulation ofChemical science · 2020Article
- An integrated electrocatalytic nESI-MS platform for quantification of fatty acid isomers directly from untreated biofluids.Chemical science · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of new electrosynthetic pathways enables environmentally friendly synthetic applications. However, the development of miniaturized screening procedures/platforms to expedite the discovery of electrooxidation reactions remains challenging. Herein, we developed an integrated system that serves as a reactor and ion source in a single experimental step using only picomole-scale reactants to monitor electrooxidation in real-time. This reaction screening platform utilizes the intrinsic electrochemical capabilities of nano-electrospray ionization mass spectrometry. We validated the feasibility of this method by reproducing three known electrochemical reactions. We also discovered two new electroorganic reaction pathways: (i) C-N dehydrodimerization of 8-methyl-1,2,3,4-tetrahydroquinoline to construct a novel quinoline skeleton, and (ii) TEMPO-mediated accelerated electrooxidative dehydrogenation of tetrahydroisoquinolines. Moreover, the radical cations and key intermediates captured by this screening platform provided direct evidence for the mechanism of these novel electrochemical reactions.
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Registered trials
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