ArticleInternational journal of preventive medicine2018
Effects of Olive Oil supplementation on Sodium Arsenate-induced Hepatotoxicity in Mice.
Article in International journal of preventive medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Bio and Geno-toxic Activities of Cadmium- Arsenic Salts Combination And/or Fluoride in Female Rats Confirmed by Molecular Docking.Biological trace element research · 2026Article
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- Protective Effect ofToxics · 2025Article
- Comparative effect of olive oil and flaxseed oil on drug induced hepatotoxicity in rats.Food science & nutrition · 2024Article
- Sinapic acid attenuates cyclophosphamide-induced liver toxicity in mice by modulating oxidative stress, NF-κB, and caspase-3.Iranian journal of basic medical sciences · 2023Article
- Tyrosol and Olive Oil Ameliorate Sodium Arsenate-Induced Nephrotoxicity by Modulating of Oxidative Stress and Histological Changes in Mice.International journal of preventive medicine · 2023Article
- PINK1/Parkin-Mediated Mitophagy Partially Protects against Inorganic Arsenic-Induced Hepatic Macrophage Polarization in Acute Arsenic-Exposed Mice.Molecules (Basel, Switzerland) · 2022Article
- Effects of Coix Seed Oil on High Fat Diet-Induced Obesity and Dyslipidemia.Foods (Basel, Switzerland) · 2022Article
- Alleviation of cisplatin-induced hepatotoxicity and nephrotoxicity by L-carnitine.Iranian journal of basic medical sciences · 2022Article
- Quercetin ameliorates Di (2-ethylhexyl) phthalate-induced nephrotoxicity by inhibiting NF-κB signaling pathway.Toxicology research · 2022Article
- Alleviation of cisplatin-induced hepatotoxicity by gliclazide: Involvement of oxidative stress and caspase-3 activity.Pharmacology research & perspectives · 2021Article
- Ameliorative role of bosentan, an endothelin receptor antagonist, against sodium arsenite-induced renal dysfunction in rats.Environmental science and pollution research international · 2021Article
- Phytoremedial effect of Tinospora cordifolia against arsenic induced toxicity in Charles Foster rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2020Article
- Acute oral toxicity evaluation ofToxicology reports · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSodium arsenate (As), a toxic substance with induced oxidative stress, lead to hepatotoxicity. Olive oil (OO) with antioxidant property has protective effect on toxicity. The aim of this study was to investigate protective effect of OO on sodium As-induced hepatotoxicity in mice. SUBJECTS AND
methodsIn this experimental study, 32 adult male BALB/c mice were divided randomly into four groups: control group (received only normal saline, the same volume as other groups), OO (0.4 mL/day, gavage), sodium As (15 mg/kg, gavage), and OO + sodium As (received OO 1 h before sodium As). Drugs were given for 30 consecutive days. After the last receipt of the drugs, oxidative stress parameters [malondialdehyde (MDA), glutathione (GSH)] in tissue, liver function parameters [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)] in serum, ferric reducing ability of plasma (FRAP) in plasma, and histopathological assays were performed.
resultsSodium As induced hepatic injury as indicated by significant increase in AST, ALT, ALP, and LDH in serum and pathologic evidences. It also induces hepatic oxidative stress biomarkers as indicated by significant increase in levels of MDA and significant decrease in FRAP and GSH concentration. OO administration significantly improved oxidative stress parameters, histopathological changes, and enzymatic markers of liver injury.
conclusionsIt was concluded that antioxidant activity of OO has hepatoprotective effect on As-induced hepatic injury.
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