Evidence map›Paper›PMID 30079092›Full record

ArticleStem cells international2018

MicroRNA-1 Regulates the Differentiation of Adipose-Derived Stem Cells into Cardiomyocyte-Like Cells.

Can Chen, Quanxiang Yan, Yiguang Yan, Mudi Ma, Yuan He, Xiaorong Shui, Zhigang Yang, Xiaozhong Lan, Yaoliang Tang, Wei Lei

Open access · goldAbstract read
In one paragraph

Article in Stem cells international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Signaling pathways and targeted therapy for myocardial infarction.Signal transduction and targeted therapy · 2022
    Review
  5. Review
  6. [Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Can ChenLaboratory of Cardiovascular Diseases, Guangdong Medical University, Zhanjiang 524001, China.ORCID 0000-0001-9205-0221
Quanxiang YanCardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Yiguang YanLaboratory of Cardiovascular Diseases, Guangdong Medical University, Zhanjiang 524001, China.
Mudi MaLaboratory of Cardiovascular Diseases, Guangdong Medical University, Zhanjiang 524001, China.
Yuan HeCardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Xiaorong ShuiLaboratory of Vascular Surgery, Guangdong Medical University, Zhanjiang 524001, China.
Zhigang YangDepartment of Hematology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Xiaozhong LanMedicinal Plants Research Centre, Tibet Agricultural and Animal Husbandry College, Nyingchi 860000, China.
Yaoliang TangVascular Biology Center, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0002-8372-1545
Wei LeiLaboratory of Cardiovascular Diseases, Guangdong Medical University, Zhanjiang 524001, China.ORCID 0000-0002-4033-4799
Guangdong Medical College · CNAugusta University · USTibet University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell transplantation is one of most valuable methods in the treatment of myocardial infarction, and adipose-derived stem cells (ASCs) are becoming a hot topic in medical research. Previous studies have shown that ASCs can be differentiated into cardiomyocyte-like cells, but the efficiency and survival rates are low. We investigated the role and mechanism of microRNA-1 (miR-1) in the differentiation of ASCs into cardiomyocyte-like cells. ASCs and cardiomyocytes were isolated from neonatal rats. We constructed lentivirus for overexpressing miR-1 and used DAPT, an antagonist of the Notch1 pathway, for

Identifiers

PMID30079092
PMCPMC6031074
OpenAlexW2796297947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.