Evidence map›Paper›PMID 30079001›Full record

ArticleContrast media & molecular imaging2018

Tang Tang, Anthony Valenzuela, Fanny Petit, Sarah Chow, Kevin Leung, Fredric Gorin, Angelique Y Louie, Marc Dhenain

Open access · hybridAbstract read
In one paragraph

Article in Contrast media & molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Towards Photoswitchable Contrast Agents for Absolute 3D Temperature MR Imaging.Angewandte Chemie (International ed. in English) · 2021
    Article
  11. Review
  12. Review
  13. Magnetic Nanoparticles as MRI Contrast Agents.Topics in current chemistry (Cham) · 2020
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Towards a nanoparticle-based prophylactic for maternal autoantibody-related autism.Nanomedicine : nanotechnology, biology, and medicine · 2019
    Article
  19. Review
  20. Advances in nanoprobes for molecular MRI of Alzheimer's disease.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Tang TangChemistry Graduate Group, University of California, Davis, CA 95616, USA.ORCID 0000-0003-3149-3322
Anthony ValenzuelaDepartment of Neurology, School of Medicine, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA.ORCID 0000-0001-9507-355X
Fanny PetitCentre National de la Recherche Scientifique (CNRS), Neurodegenerative Diseases Laboratory, Université Paris-Sud, Université Paris-Saclay, UMR 9199, 92260 Fontenay-aux-Roses, France.
Sarah ChowDepartment of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Kevin LeungDepartment of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Fredric GorinDepartment of Neurology, School of Medicine, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA.
Angelique Y LouieChemistry Graduate Group, University of California, Davis, CA 95616, USA.ORCID 0000-0001-6610-5356
Marc DhenainCentre National de la Recherche Scientifique (CNRS), Neurodegenerative Diseases Laboratory, Université Paris-Sud, Université Paris-Saclay, UMR 9199, 92260 Fontenay-aux-Roses, France.ORCID 0000-0001-8804-4101
University of California, Davis · USUniversité Paris-Sud · FR

Funding

Multimodal mPET &mMRI Imaging InstrumentationR01EB000993 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHERRY, SIMON R, JACOBS, RUSSELL E · 2004 to 2013
$9.2M
Nontoxic Si Nanoprobes for Mulitple Biomarker ImagingR01EB008576 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LOUIE, ANGELIQUE Y · 2008 to 2011
$1.3M
NIBIB NIH HHS R01 EB000993NIBIB NIH HHS R01 EB008576
6 · The paper itself

Abstract

Microglia are intrinsic components of the brain immune system and are activated in many central nervous system disorders. The ability to noninvasively image these cells would provide valuable information for both research and clinical applications. Today, most imaging probes for activated microglia are mainly designed for positron emission tomography (PET) and target translocator proteins that also reside on other cerebral cells. The PET images obtained are not specific for microglia-driven inflammation. Here, we describe a potential PET/MRI multimodal imaging probe that selectively targets the scavenger receptor class A (SR-A) expressed on activated microglia. These sulfated dextran-coated iron oxide (SDIO) nanoparticles are avidly taken up by microglia and appear to be nontoxic when administered intravenously in a mouse model. Intravenous administration of this SDIO demonstrated visualization by T

Indexed as

AnimalsEncephalitisFerric CompoundsMagnetic Resonance ImagingMagnetite NanoparticlesMiceMicrogliaMultimodal ImagingPositron-Emission TomographyScavenger Receptors, Class AFerric Compoundsferric oxideMagnetite NanoparticlesMsr1 protein, mouseScavenger Receptors, Class A

Identifiers

PMID30079001
PMCPMC6036843
OpenAlexW2810601572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.