ArticleIndian journal of dermatology
Fixed-drug Eruptions: What can we Learn from a Case Series?
Article in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Delayed Drug Hypersensitivity: Mechanistic Advances and Emerging Therapies.Current allergy and asthma reports · 2026Review
- Fixed drug eruption misdiagnosed as herpes simplex virus infection.Canadian family physician Medecin de famille canadien · 2025Article
- Fixed drug eruption induced by Etoricoxib in Thailand: A case report.Toxicology reports · 2025Article
- Fixed drug eruption mimicking syphilitic balanitis of Follmann.Infection · 2025Article
- A Saudi Woman with Ceftriaxone Induced Fixed Drug Eruption.Case reports in dermatological medicine · 2024Article
- Photobiomodulation Therapy for Multiple Painful Fixed Drug Eruptions: The First Case Report.Journal of lasers in medical sciences · 2023Article
- Fixed Drug Eruption: An Underrecognized Cutaneous Manifestation of a Drug Reaction in the Primary Care Setting.Cureus · 2022Article
- Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity.Cureus · 2021Article
- Comparison of Sensitivities of Skin Prick and Intradermal Tests with Oral Rechallenge Test: A Prospective Interventional Hospital-Based Study.Indian journal of dermatologyArticle
- Multivitamins as a Culprit of Fixed Drug Eruption.Indian journal of dermatologyArticle
- Symmetrical Drug-Related Intertriginous and Flexural Exanthema Caused by Oral Cefadroxil in a Patient with Hepatitis B-Induced Liver Cirrhosis and Psoriasis Vulgaris.Indian journal of dermatologyArticle
- Fixed drug eruption - Experience from a tertiary care center in Uttarakhand.Indian journal of pharmacologyArticle
- Azithromycin-Induced Generalized Nonbullous Fixed-Drug Eruption.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA fixed-drug eruption (FDE) is a unique cutaneous adverse drug effect in the form of recurrent lesions at the same site after re-exposure to the offending agent.
aimThe aim of the study was to identify changes in trends in fixed drug eruptions with regard to causative drug or patient risk factors.
methodsCases of FDEs encountered between March 2014 to May 2017 during routine pharmacovigilance activities were analyzed.
resultsFDEs made up 8.4% of total adverse drug reactions and 11.1% of cutaneous reactions. Majority of the patients were adults between 18 and 45 years old. The average lag period between drug intake and appearance of FDE was 2.04 days. Commonly affected sites were extremities, lips, head and neck, and genitalia. Number of FDE lesions varied from 1 to > 6, with nearly half the patients (46%) presenting with a single lesion. Antimicrobials (80.6%) and nonsteroidal anti-inflammatory drugs (20.8%) were most frequent drugs implicated. Route of administration was oral for all causative drugs. History of an FDE was positive in 26 (50.2%) of the cases. Majority of the patients (21 out of 25 or 84%) whose lesions appeared within minutes to hours of suspected drug intake had a history of FDE. Furthermore, 66.7% of patients with multiple lesions had a history of FDE while only 34.8% of patients with a single lesion had such a history.
conclusionFDEs are common cutaneous reactions with antimicrobials and anti-inflammatory agents, with increased likelihood of extensive and multiple lesions in patients with a history of FDE.
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