ArticleIndian journal of dermatology
Plasma Thiol Levels are Associated with Disease Severity in Nonsegmental Vitiligo.
Article in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Thiol-Disulfide Homeostasis in Skin Diseases.Journal of clinical medicine · 2022Review
- Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Variations of Thiol-Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria.Journal of clinical medicine · 2021Article
- Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis.Metabolites · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitiligo is a depigmenting cutaneous disorder with complex pathogenesis. Thiol compounds are well-known organic structures that play a major role in melanogenesis.
aimThe aim of this study was to determine the association between plasma thiol level and disease severity in patients with nonsegmental vitiligo.
methodsA total of 73 patients with nonsegmental vitiligo (57 generalized and 16 localized type) and age- and sex-matched 69 healthy controls were enrolled in the study. Plasma levels of native thiols, disulfides, and total thiols were measured by a novel and automated assay. Disease severity of vitiligo was assessed with Vitiligo Area Scoring Index (VASI) score. The extent, stage, and spread of vitiligo of patients were evaluated according to the Vitiligo European Task Force (VETF) system.
resultsThe native and total thiol levels of vitiligo patients were higher than those of healthy control group (
conclusionAlthough plasma native thiol level significantly correlated with VASI scores of patients, it is not a predictive factor for vitiligo severity.
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