ArticleApplied physics letters2018
Pulse inversion enhances the passive mapping of microbubble-based ultrasound therapy.
Article in Applied physics letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- A PVDF Receiver for Acoustic Monitoring of Microbubble-Mediated Ultrasound Brain Therapy.Sensors (Basel, Switzerland) · 2023Article
- Reactive oxidative species (ROS)-based nanomedicine for BBB crossing and glioma treatment: current status and future directions.Frontiers in immunology · 2023Review
- Contrast-Free Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening Using Diffusion Tensor Imaging.IEEE transactions on bio-medical engineering · 2021Article
- Focused Ultrasound-Mediated Blood-Brain Barrier Opening Increases Delivery and Efficacy of Etoposide for Glioblastoma Treatment.International journal of radiation oncology, biology, physics · 2021Article
- Linear Signal Cancellation of Nonlinear Pulsing Schemes in a Verasonics Research Scanner.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Temporal stability of lipid-shelled microbubbles during acoustically-mediated blood-brain barrier opening.Frontiers in physics · 2020Article
- Enhanced Detection of Bubble Emissions Through the Intact Spine for Monitoring Ultrasound-Mediated Blood-Spinal Cord Barrier Opening.IEEE transactions on bio-medical engineering · 2020Article
- A Clinical System for Non-invasive Blood-Brain Barrier Opening Using a Neuronavigation-Guided Single-Element Focused Ultrasound Transducer.Ultrasound in medicine & biology · 2020Article
- Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability.The British journal of radiology · 2019Review
- Non-invasive optogenetics with ultrasound-mediated gene delivery and red-light excitation.Brain stimulationArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Therapeutic ultrasound combined with preformed circulating microbubbles has enabled non-invasive and targeted drug delivery into the brain, tumors, and blood clots. Monitoring the microbubble activity is essential for the success of such therapies; however, skull and tissues limit our ability to detect low acoustic signals. Here, we show that by emitting consecutive therapeutic pulses of inverse polarity, the sensitivity in the detection of weak bubble acoustic signals during blood-brain barrier opening is enhanced compared to therapeutic pulses of the same polarity. Synchronous passive mapping of the cavitation activity was conducted using delay-and-sum beamforming with absolute time delays, which offers superior spatial resolution compared to the existing asynchronous passive imaging techniques. Sonication with pulse inversion allowed filter-free suppression of the tissue signals by up to 8 dB in a tissue-mimicking phantom and by 7 dB
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.