Evidence map›Paper›PMID 30078842›Full record

ReviewInternational journal of oral science2018

MicroRNAs and immunity in periodontal health and disease.

Xianghong Luan, Xiaofeng Zhou, Afsar Naqvi, Marybeth Francis, Deborah Foyle, Salvador Nares, Thomas G H Diekwisch

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of oral science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06261723 (Effect of Non-chirurgical Periodontal Treatment on the Innate and Adaptive Immunity From a Gender Perspective), which is not on this map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06261723 completednot on this mapstarted 2024, after this paper: background citation

Effect of Non-chirurgical Periodontal Treatment on the Innate and Adaptive Immunity From a Gender Perspective: Potential Therapeutic Implications of microRNAs

Typeobservational_patient_registrySponsorMilagros Rocha BarajasRan2024 to 2025Enrolled100ConditionsPeriodontal DiseasesArmsnon-chirurgical periodontal treatment
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Non-Coding RNAs in Oral Diseases: From Pathogenesis to Clinical Translation.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. MicroRNAs modulation by isodrimeninol fromFrontiers in oral health · 2025
    Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xianghong LuanDepartment of Oral Biology, UIC College of Dentistry, Chicago, IL, USA.
Xiaofeng ZhouDepartment of Periodontics, UIC College of Dentistry, Chicago, IL, USA.
Afsar NaqviDepartment of Periodontics, UIC College of Dentistry, Chicago, IL, USA.
Marybeth FrancisDepartment of Oral Biology, UIC College of Dentistry, Chicago, IL, USA.
Deborah FoyleDepartment of Periodontics, Texas A&M College of Dentistry, Chicago, IL, USA.
Salvador NaresDepartment of Periodontics, UIC College of Dentistry, Chicago, IL, USA. snares@uic.edu.
Thomas G H DiekwischDepartment of Periodontics, Texas A&M College of Dentistry, Chicago, IL, USA. diekwisch@tamhsc.edu.
University of Illinois Chicago · USAmerican Academy of Periodontology Foundation · US

Funding

Small molecule mediated restoration of periodontal homeostasis through the YAP1 pathwayR01DE026198 · NIDCR · UNIVERSITY OF ROCHESTER · PI DIEKWISCH, TOM · 2017 to 2021
$1.7M
NIDCR NIH HHS R01 DE026198
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are critical regulators of the host immune and inflammatory response against bacterial pathogens. In the present review, we discuss target genes, target gene functions, the potential regulatory role of miRNAs in periodontal tissues, and the potential role of miRNAs as biomarkers and therapeutics. In periodontal disease, miRNAs exert control over all aspects of innate and adaptive immunity, including the functions of neutrophils, macrophages, dendritic cells and T and B cells. Previous human studies have highlighted some key miRNAs that are dysregulated in periodontitis patients. In the present study, we mapped the major miRNAs that were altered in our reproducible periodontitis mouse model relative to control animals. The miRNAs that were upregulated as a result of periodontal disease in both human and mouse studies included miR-15a, miR-29b, miR-125a, miR-146a, miR-148/148a and miR-223, whereas miR-92 was downregulated. The association of individual miRNAs with unique aspects of periodontal disease and their stability in gingival crevicular fluid underscores their potential as markers for periodontal disease progression or healthy restitution. Moreover, miRNA therapeutics hold great promise for the future of periodontal therapy because of their ability to modulate the immune response to infection when applied in conjunction with synthetic antagomirs and/or relatively straightforward delivery strategies.

Indexed as

Adaptive ImmunityAnimalsBiomarkersDisease ProgressionHumansImmunity, InnateMicroRNAsPeriodontal DiseasesBiomarkersMicroRNAs

Identifiers

PMID30078842
PMCPMC6080405
OpenAlexW2883789112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.