Evidence map›Paper›PMID 30078765›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2018

A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika.

Jesse H Erasmus, Amit P Khandhar, Jeff Guderian, Brian Granger, Jacob Archer, Michelle Archer, Emily Gage, Jasmine Fuerte-Stone, Elise Larson, Susan Lin and 6 more

Abstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Controlling timing and location in vaccines.Advanced drug delivery reviews · 2020
    Pooled it
  2. A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Trial
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  8. Host Responses to SARS-CoV-2 with an Emphasis on Cytokines.International journal of molecular sciences · 2026
    Review
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jesse H ErasmusInfectious Disease Research Institute, Seattle, WA, USA. Electronic address: jesse.erasmus@idri.org.
Amit P KhandharInfectious Disease Research Institute, Seattle, WA, USA. Electronic address: amit.khandhar@idri.org.
Jeff GuderianInfectious Disease Research Institute, Seattle, WA, USA.
Brian GrangerInfectious Disease Research Institute, Seattle, WA, USA.
Jacob ArcherInfectious Disease Research Institute, Seattle, WA, USA.
Michelle ArcherInfectious Disease Research Institute, Seattle, WA, USA.
Emily GageInfectious Disease Research Institute, Seattle, WA, USA; University of Washington, Department of Global Health, Seattle, WA, USA.
Jasmine Fuerte-StoneInfectious Disease Research Institute, Seattle, WA, USA.
Elise LarsonInfectious Disease Research Institute, Seattle, WA, USA.
Susan LinInfectious Disease Research Institute, Seattle, WA, USA.
Ryan KramerInfectious Disease Research Institute, Seattle, WA, USA.
Rhea N ColerInfectious Disease Research Institute, Seattle, WA, USA; University of Washington, Department of Global Health, Seattle, WA, USA; PAI Life Sciences Inc., Seattle, WA, USA.
Christopher B FoxInfectious Disease Research Institute, Seattle, WA, USA.
Dan T StinchcombInfectious Disease Research Institute, Seattle, WA, USA.
Steven G ReedInfectious Disease Research Institute, Seattle, WA, USA; University of Washington, Department of Global Health, Seattle, WA, USA.
Neal Van HoevenInfectious Disease Research Institute, Seattle, WA, USA; University of Washington, Department of Global Health, Seattle, WA, USA; PAI Life Sciences Inc., Seattle, WA, USA.

Funding

Development of an Innovative, Effective, RNA-based Vaccine for Zika VirusR21AI128992 · NIAID · ACCESS TO ADVANCED HEALTH INSTITUTE · PI VAN HOEVEN, NEAL SCOTT · 2016 to 2017
$491k
Development of a novel replicating viral RNA vaccine platformF32AI136371 · NIAID · UNIVERSITY OF WASHINGTON · PI ERASMUS, JESSE HONG-SAE · 2018 to 2020
$165k
NIAID NIH HHS F32 AI136371NIAID NIH HHS R21 AI128992
6 · The paper itself

Abstract

Since the first demonstration of in vivo gene expression from an injected RNA molecule almost two decades ago,

Indexed as

AnimalsAntigens, ViralDisease Models, AnimalDrug Delivery SystemsHumansLipidsMiceNanoparticlesRNA, ViralVirus ReplicationZika VirusZika Virus InfectionAntigens, ViralLipidsRNA, Viralalphavirusemulsionflavivirusnanostructured lipid carriernon-viral deliveryrepliconRNA deliveryRNA vaccinesZika virus

Identifiers

PMID30078765
PMCPMC6171036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.