Evidence map›Paper›PMID 30078713›Full record

ArticleJournal of geriatric oncology2019

Chronic inflammation and risk of lung cancer in older adults in the health, aging and body composition cohort study.

Joshua Demb, Esther K Wei, Monika Izano, Stephen Kritchevsky, Helen Swede, Anne B Newman, Michael Shlipak, Tomi Akinyemiju, Steven Gregorich, Dejana Braithwaite

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Joshua DembDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States; Department of Oncology, Georgetown University, Washington, DC, United States. Electronic address: Josh.demb@ucsf.edu.
Esther K WeiCalifornia Pacific Medical Center Research Institute, San Francisco, CA, United States. Electronic address: WeiE@cpmcri.org.
Monika IzanoDepartment of Epidemiology, University of California, Berkeley, CA, United States.
Stephen KritchevskyWake Forest School of Medicine, Winston-Salem, NC, United States. Electronic address: skritche@wakehealth.edu.
Helen SwedeDepartment of Community Medicine and Healthcare, University of Connecticut School of Medicine, Farmington, CT, United States. Electronic address: hswede@uchc.edu.
Anne B NewmanSchool of Public Health, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: newmana@edc.pitt.edu.
Michael ShlipakDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States. Electronic address: Michael.Shlipak@ucsf.edu.
Tomi AkinyemijuDepartment of Epidemiology, University of Kentucky, Lexington, KY, United States. Electronic address: tomiakin@uky.edu.
Steven GregorichDepartment of Medicine, University of California, San Francisco, CA, United States. Electronic address: Steven.Gregorich@ucsf.edu.
Dejana BraithwaiteDepartment of Oncology, Georgetown University, Washington, DC, United States. Electronic address: Dejana.Braithwaite@georgetown.edu.
University of California, San Francisco · USCalifornia Pacific Medical Center · USGeorgetown University · USUniversity of California, Berkeley · USUniversity of Connecticut · USUniversity of Kentucky · USUniversity of Pittsburgh · USWake Forest University · US

Funding

RESOURCE CENTER FOR AGING RESEARCH IN DIVERSE POPULATIONP30AG015272 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Torsten Brian Neilands · 1997 to 2026
$19.5M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101N01AG062101 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1996 to 2004
$996k
DYNAMICS OF HEALTH . AGING . AND BODY COMPOSITION /Memphis/-26062103N01AG062103 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 1996 to 2004
$793k
HEALTH ABC--COORDINATING UNIT /California/-260062106N01AG062106 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 1996 to 2004
$109k
The Role of Structural Factors in Mammography Screening Behavior in the United StatesF31CA210399 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEMB, JOSHUA BRIAN · 2017 to 2018
$68k
NCI NIH HHS F31 CA210399NIAMS NIH HHS P30 AR066262NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS P30 AG015272NIA NIH HHS R01 AG028050NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

objectivesWe examined the association between three inflammatory markers (Interleukin (IL)-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-α) and incident lung cancer using baseline, updated, and averaged inflammatory measures in older adults.

methodsWe fitted multivariable Cox models to assess whether circulating levels of inflammation markers were associated with incident lung cancers in the Health Aging, Body and Composition (HealthABC) prospective cohort of 3075 older adults aged 70-79 years at baseline. IL-6 and CRP were measured biennially, whereas TNF-α was measured at baseline.

resultsBaseline levels of IL-6 were significantly associated with incident lung cancer risk in a model that adjusted for age, gender, race, and site (Model 1) (Hazard Ratio

conclusionsBaseline CRP and IL-6 levels were associated with increased risk of lung cancer in Model 1 and both models, respectively. Chronic IL-6 inflammation, as quantified by repeated measures was associated with incident lung cancer in Model 1, but not Model 2. Further research is needed to understand the role of CRP and IL-6 in lung carcinogenesis.

Indexed as

AgedAged, 80 and overBiomarkersBlack or African AmericanChronic DiseaseCohort StudiesC-Reactive ProteinFemaleHumansIncidenceInflammationInterleukin-6Lung NeoplasmsMaleMultivariate AnalysisProportional Hazards ModelsBiomarkersC-Reactive ProteinIL6 protein, humanInterleukin-6TNF protein, humanTumor Necrosis Factor-alphaIncidenceInflammatory markersLung cancerPulmonary

Identifiers

PMID30078713
PMCPMC6653636
OpenAlexW2887417587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.